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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831147/
PSEUDOVIRIONS AS A CLASS OF DELIVERY VEHICLES. One of the obstacles to the therapeutic use of siRNA is that of delivery. Some aspects of delivery include: targeted delivery into various cell types, transducing dividing and quiescent cells, and crossing the blood-brain barrier.Author: Paul E. Lund, Ryan C. Hunt, Michael M. Gottesman, Chava Kimchi-Sarfaty
https://www.researchgate.net/publication/40484871_Pseudovirions_as_Vehicles_for_the_Delivery_of_siRNA
Pseudovirions as vehicles for the delivery of siRNA Paul E. Lund 1 , Ryan C. Hunt 2 , Michael M. Gottesman 1 , and Chava Kimchi-Sarfaty 2,* 1 Laboratory of Cell Biology, National Cancer Institute ...
https://www.ncbi.nlm.nih.gov/pubmed/19998056
Pseudovirions as vehicles for the delivery of siRNA. Lund PE(1), Hunt RC, Gottesman MM, Kimchi-Sarfaty C. Author information: (1)Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.Author: Paul E. Lund, Ryan C. Hunt, Michael M. Gottesman, Chava Kimchi-Sarfaty
https://link.springer.com/article/10.1007%2Fs11095-009-0012-2
Characteristics of the pseudovirions discussed in this review, namely phagemids, HSV amplicons, SV40 in vitro-packaged vectors, influenza virosomes, and HVJ-Envelope vectors, make them attractive for the delivery of siRNA-based therapeutics. Pseudovirions were shown to deliver siRNA effector molecules and bring about RNA interference (RNAi) in ...Author: Paul E. Lund, Ryan C. Hunt, Michael M. Gottesman, Chava Kimchi-Sarfaty
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.690.1038
Levels of silencing were not always determined directly, but the duration of siRNA-induced knockdown lasted at least 3 days. We present examples of the use of pseudovirions for the delivery of synthetic siRNA as well as the delivery and expression of DNA-directed siRNA. KEY WORDS: pseudoviral delivery vehicle; pseudovirion; siRNA delivery.
https://www.academia.edu/13917159/Pseudovirions_as_Vehicles_for_the_Delivery_of_siRNA
Pseudovirions as Vehicles for the Delivery of siRNA
https://www.liebertpub.com/doi/10.1089/hum.2008.928
Although challenges remain, delivery represents the main hurdle for faster and broader development of siRNA therapeutics. In this review, a summary of the advances in in vivo siRNA delivery is presented and discussed. Multiple different delivery approaches have demonstrated success ranging from the relative simplicity of direct local ...Author: Antonin R. de Fougerolles
https://www.accessdata.fda.gov/scripts/publications/search_result_record.cfm?id=26156
Characteristics of the pseudovirions discussed in this review, namely phagemids, HSV amplicons, SV40 in vitro-packaged vectors, influenza virosomes, and HVJ-Envelope vectors, make them attractive for the delivery of siRNA-based therapeutics. Pseudovirions were shown to deliver siRNA effector molecules and bring about RNA interference (RNAi) in ...
https://www.sciencedirect.com/science/article/pii/S0169409X16302046
After endocytosis, siRNA-loaded delivery vehicles encounter a sequential pH drop in the early endosome (pH 6.5), late endosome (pH 6.0), and lysosome (pH 4.5–5.0) , . In this way, the endocytosed delivery vehicles (and siRNA payloads) are subjected to lysosomal hydrolysis and inactivated for RNAi machinery.Author: Hyun Jin Kim, Ahram Kim, Kanjiro Miyata, Kazunori Kataoka
https://www.cbns.org.au/projects/delivery-vehicles-for-sirna/
The star polymer siRNA delivery system is an effective therapeutic strategy for the treatment of pancreatic as well as other cancers that aberrantly express this gene or non-targetable genes. Delivery vehicles for chemotherapy. Neuroblastoma is the second-most common solid tumour in children.
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