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https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-based-vaccine
Later, in the 1980–90s, several bacterially produced protein subunit vaccines were licensed to protect against pertussis, and led to the proposal of a genetically detoxified form of the pertussis toxin (PT) that showed superior immunogenicity over chemically detoxified PT. 29 Finally, late in the 20th century, efforts to develop a vaccine against hepatitis B virus (HBV) led to the first widely implemented vaccines …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964737/
Oct 29, 2015 · Nano/micro-sized particulate vaccine delivery systems have the ability to simultaneously deliver both the antigen and the immunopotentiator to the same dendritic cells (DCs) or macrophages. 7 Co-delivery of both the antigen and immunostimulant (IS) may lead to enhanced potency, adjuvant dose reduction, and consequently minimizing toxicity of the IS. 8,9 However, the application of PLGA …Author: Mojgan Allahyari, Elham Mohit
https://www.pnas.org/content/100/9/4995
Apr 29, 2003 · However, delivery problems have limited the clinical success of protein-based vaccines, and new protein delivery vehicles capable of enhancing the efficacy of protein-based vaccines are needed. A key limitation of current protein-based vaccines is their inability to activate cytotoxic T lymphocytes (CTLs), a process that is critical for the development of immunity against viruses and …Author: Niren Murthy, Mingcheng Xu, Stephany Schuck, Jun Kunisawa, Nilabh Shastri, Jean M. J. Fréchet, Jean ...
https://www.pnas.org/content/96/17/9469
Aug 17, 1999 · The progress toward subunit vaccines has been limited by their poor immunogenicity and limited stability. To enhance the immune response, subunit vaccines universally require improved adjuvants and delivery vehicles. In the present paper, we propose the use of cross-linked protein crystals (CLPCs) as antigens.Author: Nancy St. Clair, Bhami Shenoy, Lawrence D. Jacob, Alexey L. Margolin
https://www.tandfonline.com/doi/pdf/10.1080/21645515.2015.1102804
vaccine delivery system. Antigenic proteins/peptides can be encapsulated into or adsorbed to the surface of PLGA particles. The gradual release of loaded antigens from PLGA particles is necessary for the induction of efficient immunity. Various factors can influence protein …
https://www.creative-biolabs.com/vaccine/peptide-or-protein-based-vaccines.htm
Peptide-based vaccines take advantage of the ability of computer algorithms to screen protein amino acid sequences for peptide epitopes derived from TAAs. The proteins and peptides delivered with virus vectors or in combination with immune-stimulating molecules to the body can be presented by dendritic cells that activate CD8 + T cell to generate an anticancer immune response.
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