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https://www.sciencedirect.com/science/article/pii/S0169409X15300260
Taking these considerations together, it is clear that although several protease systems are upregulated or functionally activated in the extracellular tumor environment – particularly the serine proteases of the plasminogen activation pathway, the MMPs and cysteine cathepsins – their blockade may not have the hoped-for anti-cancer therapeutic effects, even with highly specific inhibitors.Author: Jennifer Vandooren, Ghislain Opdenakker, Paul M. Loadman, Dylan R. Edwards, Dylan R. Edwards
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425417/
Nov 07, 2014 · The advent of nanomaterials-based drug delivery systems has made a seminal impact to the field of drug delivery. 1, 2 Therapeutics and diagnostic agents incorporated in versatile nanoscale particles composed of dynamic nanomaterials have been developed for the diagnosis and treatment of cancer, 3 diabetes, 4, 5 bacterial infections, 6 etc.Author: Quanyin Hu, Prateek S. Katti, Zhen Gu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
For an overview on hydrogels, see Bindu Sri et al., and for more detail on the use of hydrogels for oral peptide drug delivery, the review by Peppas et al. is helpful [103,104]. While liposome systems have potential in oral drug delivery, there is a concern with stability of the vesicles under the physiologic conditions of the GI tract .Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/abs/pii/S0169409X15300260
Proteases in cancer drug delivery ... Whereas protease inhibitors have been developed successfully against hypertension and viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling we now better understand that the tumor “degradome” (i.e. the repertoire of proteases and their natural inhibitors and ...Author: Jennifer Vandooren, Ghislain Opdenakker, Paul M. Loadman, Dylan R. Edwards, Dylan R. Edwards
https://www.researchgate.net/publication/289238832_Proteases_in_cancer_drug_delivery
Proteases in cancer drug delivery. ... However, systemic delivery of protease inhibitors can result in undesired reduction of proteolytic activity in normal tissues, leading to adverse effects and ...
http://www.thno.org/v02p0156.htm
In this way, a nanoparticle based approach for protease targeted therapeutic delivery can act as multimodal imaging and drug delivery agent - a true theranostics agent. 5. Conclusion. We have introduced key proteases that are involved in various pathologies, especially cancer, and their potential as targets for prodrugs.
https://finance.yahoo.com/news/peptide-drug-design-delivery-summit-174500297.html
Mar 03, 2020 · Peptide Drug Design & Delivery Summit: San Diego, USA, August 31st to Sept 2nd, 2020 - Examines Various Peptide Discovery & Synthesis Techniques and Synthesized & Modified Peptides
https://www.researchgate.net/publication/328265448_PROTEIN_AND_PEPTIDE_DRUG_DELIVERY_SYSTEM
Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells.
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=18&issue=12&spage=1785
Keywords: Peptide-based prodrugs, polymeric prodrugs, proteases, protease-sensitive fluorescence imaging agents, protease-sensitive chemotherapeutics, protease-sensitive photosensitizers, drug delivery, photodynamic therapy, hydrolysis of peptide, overwhelming evidence
https://www.nature.com/articles/s41598-020-62423-y
Mar 26, 2020 · Elbow region (P36–46): Probable allosteric target in the HIV-1 protease. The conventional method of drug delivery may result in adverse side effects because many enzymes with related functions ...
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