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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218546/
The observation that progesterone supplementation does not prevent preterm birth in multiple pregnancy suggests that the mechanism leading to preterm labor and delivery in multiples—namely excessive uterine stretch—is different from that in singletons (see discussion above).Author: Errol R Norwitz, Aaron B Caughey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971700/
Aug 09, 2010 · Of particular note, the largest study to date using vaginal progesterone gel identified no benefit for women with a previous preterm birth.117 However, the results of ongoing randomized trials assessing the role of intramuscular118 and vaginal119,120 progesterone in women with a history of spontaneous preterm birth will contribute information about the role of progesterone in this group of …Author: Jodie M Dodd, Caroline A Crowther
https://www.webmd.com/baby/understanding-preterm-labor-birth-prevention
This is usually done between 20 and 28 weeks of pregnancy, if necessary. Recent studies have shown that treatment with a hormone called progesterone can prevent preterm birth in certain women. Vaginal progesterone is given to pregnant women found to have a short cervix.
https://www.uhhospitals.org/for-clinicians/articles-and-news/articles/2019/02/preventing-preterm-birth
Dr. Mesiano’s team is hard at work learning more about how progesterone sustains pregnancy, and how its effects are blocked in women to induce labor. Their ultimate goal is to develop progesterone-based therapies to prevent preterm birth. CURRENT PROGESTERONE-BASED THERAPIES
https://www.marchofdimes.org/complications/progesterone-treatment-to-help-prevent-premature-birth.aspx
Progesterone is a hormone that helps your uterus grow during pregnancy and keeps it from having contractions. Treatment with progesterone during pregnancy may help some women reduce their risk for premature birth. If you have a short cervix, treatment with vaginal progesterone gel may help prevent premature birth.
https://www.mc.vanderbilt.edu/dept/obgyn/High_Risk_Conference/2012/Murtha%20-Progesterone%20update%20slides%2011-15.-12.pdf
First birth Second birth Subsequent preterm birth (%) Not preterm 4.4 Preterm 17.2 Not preterm Not preterm 2.6 Preterm Not preterm 5.7 Not preterm Preterm 11.1 Preterm Preterm 28.4 From Bakketeig LS et al,: Epigemiology of preterm birth: Results from a longitudinal study of births in Norway. In Elder MG: Preterm Labor.
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