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https://www.omicsonline.org/conferences-list/major-challenges-in-drug-delivery-system
Major Challenges in Drug Delivery Systems are delivery of poorly soluble drugs and bioavailability hurdles for poorly soluble clinical candidates. There are several Novel approaches in the delivery, Overcoming bioavailability hurdles and Rationale formulation design of poorly soluble drugs.
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · In the humid environment of the respiratory system, drug particles may readily stick together, potentially causing irritancy issues in addition to a reduction in efficacy. Various micronization technologies based on air jet-milling are available for the preparation of suitably sized nanoparticles used for pulmonary drug delivery.
https://www.ncbi.nlm.nih.gov/books/NBK200818/
One approach to addressing this problem is to improve local antibiotic delivery. Current practice is to mix daptomycin with poly(methyl methacrylate) (PMMA), also known in the biomedical community as bone cement. Bone cement, as its name implies, is not porous and there is …Author: Division on Earth
https://www.pharmaceutical-journal.com/drug-delivery-progress-and-problems/20003039.article
Professor LESLIE BENET (University of California, San Francisco) explained how oral drug delivery was affected. He said that, until relatively recently, poor oral bioavailability of a drug was thought to be related to physico-chemical problems or hepatic first pass metabolism.
https://www.tandfonline.com/loi/idrd20
Browse the list of issues and latest articles from Drug Delivery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · The current lack of clear recognition of problems facing the drug delivery field can be anticipated to result in only marginal advances in targeted drug delivery technologies in the coming years. The current unmet needs and challenges in this area were summarized by Professor Alexander T. Florence who is one of the few who raised awareness on the exaggerated claims of the nanoparticle-based drug targeting …Author: You Han Bae, Kinam Park
https://www.researchgate.net/publication/10783760_Drug_delivery_to_the_retina_Challenges_and_opportunities
The main problem in ocular drug delivery is the rapid elimination and low precorneal half-life of conventional eye drops from eye due to various types of barriers that exist in the eye [1, 2 ...
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Working backwards is sometimes an effective way to solve a problem. In drug delivery research, this means starting with a delivery method. The target may be whole organs (heart, lung, brain), tissue types (muscle, nerve), disease-specific structures (tumor cells…
https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-5-70
Nov 09, 2012 · Targeted drug delivery for cancer therapy: the other side of antibodies ... Journal of Hematology & Oncology volume 5, ... Predictably, these types of cancers are more amenable to immunotherapy where the antibodies can bypass problems faced in the treatment of solid tumors, such as tissue penetration (see below). ...Author: Michael A Firer, Gary Gellerman
https://www.sciencedirect.com/science/article/pii/S0032386108000487
Thus, the problem of hydrophobic drug delivery is two-fold: how to load the hydrophobic drug into the gel matrix and, once present, how to effectively release the drug into the aqueous gel environment. A variety of strategies have been used to improve hydrophobic drug loading into hydrogels.Author: Todd R. Hoare, Daniel S. Kohane
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