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https://www.nature.com/articles/srep14944
Oct 09, 2015 · The 2-amino thiazole scaffold present in BMD42-23 had previously been widely studied in the context of anti-prion drug discovery and had even been used in a clinical trial for prion disease 29.Author: Jae Wook Hyeon, Jiwon Choi, Su Yeon Kim, Rajiv Gandhi Govindaraj, Kyu Jam Hwang, Yeong Seon Lee, Seo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601254/
Jun 25, 2015 · In recent years, prion protein (PrP C) has been considered as a promising target molecule for cancer therapies, due its direct or indirect participation in tumor growth, metastasis, and resistance to cell death induced by chemotherapy.PrP C functions as a scaffold protein, forming multiprotein complexes on the plasma membrane, which elicits distinct signaling pathways involved in diverse ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088797
We therefore proposed to test a new therapeutic scheme using this new drug delivery technology named Aonys to deliver PrP-siRNA, first in wild type mice and then in prion infected mice. Aonys comprises exclusively pharmacopeia and GRAS listed ingredients.Author: Sylvain Lehmann, Sylvain Lehmann, Aroa Relano-Gines, Sarah Resina, Elsa Brillaud, Danielle Casanova,...
http://www.prion.ucl.ac.uk/clinic-services/research/drug-treatments/
Following anecdotal reports of improvement when taking quinacrine in a single patient with variant Creutzfeldt-Jakob disease (vCJD), two trials were initiated. The PRION-1 trial was led by Professors Collinge and Darbyshire at the National Prion Clinic, UK. Another trial based in San Francisco, USA, was led by Dr Michael Geshwind.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811144/
Apr 01, 2016 · In this article, we identified the prion-like protein doppel as a potential therapeutic target for tumor angiogenesis. We investigated the interactions between doppel and VEGFR2 and evaluated whether blocking the doppel/VEGFR2 axis suppresses the process of angiogenesis. ... For angiogenesis-specific drug delivery, one clever approach involves ...Author: Taslim A. Al-Hilal, Seung Woo Chung, Jeong Uk Choi, Farzana Alam, Jooho Park, Seong Who Kim, Sang Yo...
https://www.sciencedirect.com/science/article/pii/S0141813019351888
Drug delivery strategies combating prion diseases across the blood brain barrier, the efficacy of drugs and biocompatibility remain a serious question to be thoroughly studied for effective diagnosis and treatment. The present review compiles comprehensively the current treatment modalities against prion diseases and future prospects of ...Author: Chandrasekaran Murugesan, Paramasivan Manivannan, Muralitharan Gangatharan
https://www.sciencedirect.com/science/article/pii/S0024320520301417
Targeted drug delivery has always paved the way for delivering exclusively to specific site by pre-identifying in which compartment specific drug will exert intrinsic activity at its maximum rate and at the same time also prevent the drug's unnecessary introduction or …Author: Prabhuti Nirale, Ankita Paul, Khushwant S. Yadav
https://www.webmd.com/brain/prion-diseases
Prion diseases are a group of different conditions that affect your brain and nervous system.They can cause severe dementia or problems with body control that get worse very quickly. They're ...Author: Susan Bernstein
https://blogs.scientificamerican.com/mind-guest-blog/prions-may-develop-drug-resistance-the-implications-for-mad-cow-alzheimere28099s-and-parkinsone28099s/
Oct 16, 2013 · Prions May Develop Drug Resistance: The Implications for Mad Cow, Alzheimer’s and Parkinson’s. Clumps of proteins twisted into aberrant shapes cause the …Author: Lary C. Walker
https://www.niaid.nih.gov/news-events/drug-delivery-technology-leads-sustained-hiv-antibody-production-nih-study
A new approach to direct the body to make a specific antibody against HIV led to sustained production of that antibody for more than a year among participants in a National Institutes of Health clinical trial. This drug-delivery technology uses a harmless virus to deliver an antibody gene into human cells, enabling the body to generate the antibody over an extended time.
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