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https://www.researchgate.net/publication/226811803_Principles_of_Retinal_Drug_Delivery_from_Within_the_Vitreous
In recent years, vitreous humour, a connective tissue at the centre of the eye, emerged as a preferred reservoir for back of the eye drug delivery.
https://link.springer.com/chapter/10.1007/978-1-4419-9920-7_6
Jun 20, 2011 · In order to enable the reader with the development of personalised medicines for the back of the eye, this chapter discusses vitreal anatomy, convective flow patterns, barriers to drug delivery, drug clearance mechanisms, and the influence of vitrectomy and vitreous substitutes on drug delivery.Author: Clive G. Wilson, Lay Ean Tan, Jenifer Mains
https://pureportal.strath.ac.uk/en/publications/principles-of-retinal-drug-delivery-from-within-the-vitreous
/ Principles of retinal drug delivery from within the vitreous. Drug Product Development for the Back of the Eye. Drug Product Development for the Back of the Eye. Springer, 2011. pp. 125-158 (AAPS Advances in the Pharmaceutical Sciences Series).Author: Clive G. Wilson, Lay Ean Tan, Jenifer Mains
https://www.sciencedirect.com/science/article/pii/S1350946216300635
Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view.Author: Eva M. del Amo, Anna-Kaisa Irmeli Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, M...
https://core.ac.uk/display/9037942
Principles of retinal drug delivery from within the vitreous ... convective flow patterns, barriers to drug delivery, drug clearance mechanisms, and the influence of vitrectomy and vitreous substitutes on drug delivery. Further, it presents case studies on interactions of drug delivery systems with vitreous gel as well as the influence of eye ...Author: Clive Wilson, Lay Ean Tan and Jenifer Mains
https://strathprints.strath.ac.uk/37740/
Wilson, Clive and Tan, Lay Ean and Mains, Jenifer; () Principles of retinal drug delivery from within the vitreous. In: Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series .Author: Clive G. Wilson, Lay Ean Tan, Jenifer Mains
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications. ... information has been obtained about the biotransformation or metabolism of exogenously administered small molecules within the vitreous and retina. Thus, their impact on clearance mechanisms is generally unknown.Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
http://retinatoday.com/2016/09/drug-delivery-to-the-retina
Does drug delivery that originates from the outside of the retinal pigment epithelium (RPE) barrier differ from drug delivery from within the RPE barrier? With respect to pharmacokinetics, the answer is clearly yes. The choroidal blood flow and absence of an intervening blood-retina barrier creates access for rapid egress of drugs from the eye.
https://www.researchgate.net/publication/26332535_Inner_Blood-Retinal_Barrier_Transporters_Role_of_Retinal_Drug_Delivery
Download Citation Inner Blood-Retinal Barrier Transporters: Role of Retinal Drug Delivery The inner blood-retinal barrier (inner BRB) forms complex tight junctions of retinal capillary ...
https://clinicalgate.com/principles-of-intravitreal-application-of-drugs/
Technique for intravitreal drug injection. Topical or subconjunctival application of anesthetic with properacaine followed by 4% lidocaine soaked into a cotton-tip applicator is commonly used over the injection site, which is located inferotemporally to avoid drug deposition into the visual axis by gravity, or alternatively in the superotemporal quadrant to avoid contamination with the ...
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