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https://www.liebertpub.com/doi/abs/10.1089/108076801753162807
The delivery of drugs to the retina from solution or from prolonged release forms is considered in terms of pharmacokinetics, interference with vision, and toxicity and safety. It is concluded that visual loss will be the limiting factor in determining the useful life of a drug administered as a microdispersion.Author: David Maurice
https://www.researchgate.net/publication/11776743_Review_Practical_Issues_in_Intravitreal_Drug_Delivery
Download Citation Review: Practical Issues in Intravitreal Drug Delivery The delivery of drugs to the retina from solution or from prolonged release forms is considered in terms of ...
https://www.liebertpub.com/doi/abs/10.1089/jop.1992.8.343
A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases. Journal of Pharmaceutical Sciences, Vol. 99, No. 5. ... Review: Practical Issues in Intravitreal Drug Delivery. David Maurice; Vol. 17, No. 4 July 2004.Author: P. Ashton, J.D. Brown, P.A. Pearson, D.L. Blandford, T.J. Smith, R. Anand, S.D. Nightingale, G.E. Sa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306439/
Sep 10, 2014 · For sustained drug delivery and minimizing chances of retinal toxicity, intravitreal drug effects of delivering drugs in liposomes or microspheres have been studied which could provide therapeutic drug levels for up to a month ,. Non-biodegradable and biodegradable devices or implants have been investigated –.Author: Medikonda Radhika, Kopal Mithal, Abhishek Bawdekar, Vivek Dave, Animesh Jindal, Nidhi Relhan, Thomas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435115/
A clearance pathway of the hydrophilic probe from the subconjunctival depot to the regions near the periocular fat behind the eye was found. After intravitreal injection in vivo, the contrast agent was observed in the anterior chamber, optic nerve, and tissues surrounding the eye during clearance.Author: S. Kevin Li, Jinsong Hao, Hongshan Liu, Jing-huei Lee
https://eyewiki.aao.org/Intravitreal_Injections
Intravitreal drug delivery has become a popular method of treatment of many retinal diseases, commonly including AMD, Diabetic Retinopathy, and Retinal Vein Occlusions. The frequency of intravitreal injections has significantly increased since the introduction of Anti-VEGF medications. This is an important procedure that Retina Specialists use on a daily basis, and it is important to master the techniques of …
https://www.retinalphysician.com/issues/2009/july-aug/steps-for-a-safe-intravitreal-injection-technique
Jul 01, 2009 · INTRAVITREAL DRUG DELIVERY. The advantage of intravitreal administrations is an immediate therapeutic effect at the intended tissue. With the widespread use of intravitreal injections, there has been an increased interest regarding the best application technique. Clinical experience with intravitreal injection has provided physicians with an outline of avoidable risks.
https://www.wjgnet.com/2220-3192/full/v2/i4/78.htm
Intravitreal injection (IVI) involves delivering of the drug formulation directly into the vitreous humor through pars plana. This method provides direct access to the vitreous and avoids both the cornea and also the scleral blood vessels.Author: Deep Kwatra, Ashim K Mitra
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