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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752650/
Dec 08, 2008 · Microneedles, as the name suggests, are micron-scale needles that are employed for transdermal vaccination and drug delivery (Reed and Lye 2004). The recognition that very small needles may be sufficient for transport across the 10–20 μm-thick stratum corneum was first proposed in the 1970s ( Gerstel and Place 1976 ) but progress was delayed largely due to lack of techniques to …Author: Anubhav Arora, Mark R. Prausnitz, Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S0142961219308518
Recently, transdermal powder delivery, such as an ablative fractional laser combined with powder coated adhesive patches [23,24] or a vaccine powder-loaded microneedle patch have been introduced to deliver powdered drugs directly into the skin. These techniques delivered powdered drugs directly and thus did not require a drug reconstitution process as in DMN fabrication.Author: Suyong Kim, Huisuk Yang, Jaehong Eum, Yonghao Ma, Shayan Fakhraei Lahiji, Hyungil Jung
http://www.pharmaresearchlibrary.com/powderject-device-a-needle-free-tool-for-transdermal-drug-delivery/
The Powder Ject system of transdermal delivery of powdered drug involves the propulsion of solid drug particles into the skin by means of a high-speed gas flow. The Powder Ject system fires solid particles (20–100 µm) through stratum corneum into lower skin layers,using...
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/nanocarrier-systems-for-transdermal-drug-delivery
Skin penetration is essential to a number of current concerns, for example, contamination by microorganisms and chemicals, drug delivery to skin (dermatological treatments) and through skin (transdermal treatments), and skin care and protection (cosmetics) [ 103 - 106 ].Author: José Juan Escobar-Chávez, Isabel Marlen Rodríguez-Cruz, Clara Luisa Domínguez-Delgado, Roberto D...
https://www.merckvetmanual.com/pharmacology/pharmacology-introduction/routes-of-administration-and-dosage-forms
A special consideration relating to the use of topical dosage forms is the potential for residues in wool and mohair to occur. The topical route of administration is also used to deliver therapeutic agents systemically. Transdermal patches, for instance, are used to deliver analgesics …
https://www.sciencedirect.com/science/article/pii/0168365994901341
Topical formulations contain- ing drugs showing systemic action are called transdermal delivery systems (TDS) or trans- dermal therapeutic systems (TTS). Transder- mal delivery may be defined as the delivery of a drug through intact skin so that it reaches the systemic circulation in sufficient quantity to be beneficial after administration of a therapeutic dose.Author: Kenji Sugibayashi, Yasunori Morimoto
https://www.researchgate.net/publication/316728521_Liquid_and_Powder_Jet_Injectors_in_Drug_Delivery_Mechanisms_Designs_and_Applications
Liquid and Powder Jet Injectors in Drug Delivery: Mechanisms, Designs, and Applications ... of hydrogen or helium instead of the conventional powder gas. The first gun built, the design of which ...Author: Anubhav Arora
https://en.wikipedia.org/wiki/Jet_injector
A jet injector is a type of medical injecting syringe device used for a method of drug delivery known as jet injection, in which a narrow, high- pressure stream of liquid penetrates without needle the outermost layer of the skin (stratum corneum) to deliver medication to targeted underlying tissues of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5]. The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2013.879355
Transdermal delivery Transdermal delivery can be defined as the application of a drug to the skin for treat systemic disease. The main aim of this delivery is achieving systemically active levels of the drug. The main important requisite for this delivery is percutaneous absorption with appreciable systemic drug accumulation.
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