Potential New Methods For Antiepileptic Drug Delivery

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Potential New Methods for Antiepileptic Drug Delivery ...

    https://link.springer.com/article/10.2165/00023210-200216090-00001
    Aug 29, 2012 · Use of novel drug delivery methods could enhance the efficacy and reduce the toxicity of antiepileptic drugs (AEDs). Slow-release oral forms of medication In emergency situations, administration via rectal, nasal or buccal mucosa can deliver the drug …Author: Robert S. Fisher, Jet Ho

Potential New Methods for Antiepileptic Drug Delivery

    https://www.researchgate.net/publication/11230246_Potential_New_Methods_for_Antiepileptic_Drug_Delivery
    The common feature of the method is the use of some type of antiepileptic drug (AED) delivery device placed inside the cranium to prevent or stop focal seizures.

18242 Stanford Health Care

    https://stanfordhealthcare.org/publications/182/18242.html
    Use of novel drug delivery methods could enhance the efficacy and reduce the toxicity of antiepileptic drugs (AEDs). Slow-release oral forms of medication or depot drugs such as skin patches might improve compliance and therefore seizure control.

New Routes for Delivery of Anti-Epileptic Medications

    http://www.ant-tnsjournal.com/Mag_Files/15-4/dw200612251570_15-4%20p225.pdf
    of drug delivery to the peripheral system, then potential new methods of targeted CNS drug delivery. Intrathecal or intraventricular AEDs might circumvent systemic toxicity. Drug-eluting wafers could be sur-gically positioned over an epileptogenic region of brain. Drug can be delivered to a seizure focus by an implanted catheter and subcutaneous pump.

Novel methods of antiepileptic drug delivery — Polymer ...

    https://www.sciencedirect.com/science/article/pii/S0169409X1200124X
    Casting is the most simple of the methods used to produce monolithic drug carriers. The process involves liquefying the polymer, adding the drug to the liquid polymer, and then pouring the solution or mixture into a mould and allowing the polymer to solidify again.Author: Amy J. Halliday, Simon E. Moulton, Gordon G. Wallace, Mark J. Cook

Nanotechnology for delivery of drugs to the brain for epilepsy

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673491/
    To improve the efficacy of AEDs, new drug delivery strategies are being developed; these methods fall into the three main categories: drug modification, blood—brain barrier modification, and direct drug delivery. Recently, all three methods have been improved through the use of drug …Author: Margaret F. Bennewitz, W. Mark Saltzman

Nanoparticle-based targeted drug delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
    Novel nanosystems can be pre-programmed to alter their structure and properties during the drug delivery process, allowing for more effective extra- and intra-cellular delivery of encapsulated drug (Wagner, 2007). This is achieved by the incorporation of molecular sensors that respond to physical or biological stimuli, including changes in pH, redox potential, or enzymes.Author: Rajesh Singh, James W. Lillard, James W. Lillard

Antiepileptic drugs in development - The Lancet Neurology

    https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(06)70627-5/fulltext
    Dec 01, 2006 · Talampanel, a new compound, is the first antiepileptic drug in development with a mechanism of AMPA antagonism. The drug acts at the AMPA receptor non-competitively via allosteric modulation of the receptor site.Author: John R Pollard, Jacqueline French

Electrophoretic drug delivery for seizure control ...

    https://advances.sciencemag.org/content/4/8/eaau1291.full
    Aug 01, 2018 · Having benchmarked the drug delivery capacity, we used epilepsy as a model system to test the therapeutic potential of the μFIP implant. Seizure-like events (SLEs) were induced by local injection of 4-aminopyridine (4AP) into the hippocampus of anesthetized mice following previously reported procedures (Fig.Author: Christopher Michael Proctor, Christopher Michael Proctor, Andrea Slézia, Attila Kaszas, Antoine Ghes...

Small-scale systems for in vivo drug delivery Nature ...

    https://www.nature.com/articles/nbt876
    Sep 30, 2003 · New approaches include the on-demand activation of molecular interactions, novel diffusion-controlled delivery devices, nanostructured 'smart' surfaces and materials, and prospects for …Author: David A LaVan, Terry McGuire, Robert Langer

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