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https://www.aao.org/eyenet/article/drug-delivery-for-the-posterior-segment
Grewal points to Vitrasert (Chiron, later Bausch + Lomb), the first sustained-release posterior segment drug delivery system that laid some of the foundation for today’s breakthroughs. Approved by the FDA in March 1996, Vitrasert consists of a 4.5 mg pellet of ganciclovir coated with a biocompatible polymer and is designed to deliver the drug over five to eight months.
https://www.healio.com/ophthalmology/journals/osli/2020-3-51-3/{78be47c3-c13e-4bfa-bfd9-99a216a65561}/emerging-drug-delivery-systems-for-posterior-segment-disease
In summary, a number of emerging drug delivery platforms are under investigation for diseases of the posterior segment and are needed for both retina and uveitis specialists.
https://www.aao.org/Assets/7eb06ca0-e49a-4f72-97d6-50d9ae12a8b3/636917545446730000/may-2019-feature-pdf
release posterior segment drug delivery system that laid some of the foundation for today’s breakthroughs. Approved by the FDA in March 1996, Vitrasert consists of a 4.5 mg pellet of ganciclovir coated with a biocompatible polymer and is designed to deliver the drug over five to eight months. It was indicat-ed for the local treatment of
https://www.oraclinical.com/resource/the-renaissance-of-drug-delivery-systems-for-the-posterior-segment/
Drug delivery to the posterior segment is hampered by the anatomy of the eye due to its inherent design, which dilutes and removes foreign material. In topically administered treatments, more than 90% of the drug from an eye drop will be lost before making it past the tear film.
https://www.retinalphysician.com/issues/2007/september-2007/drug-delivery-to-the-posterior-segment
Sep 01, 2007 · Their use in posterior-segment drug delivery focuses on their ability to reduce toxicity of drugs, prolong the half-life of drugs, and deliver drugs specifically to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575283/
Intravitreal delivery of pharmacologic agents is the key method of drug delivery for posterior segment disease including retinal vascular disorders and posterior uveitis.Author: William Pearce, Jason Hsu, Steven Yeh
https://www.sciencedirect.com/science/article/pii/S0002939409000026
The corticosteroid dexamethasone has potent anti-inflammatory properties, and a recent study demonstrated that dexamethasone in a novel biodegradable drug delivery system (Dexamethasone Posterior Segment Drug Delivery System [dexamethasone DDS]; Allergan Inc, Irvine, California, USA) can produce improvements in best-corrected visual acuity (BCVA), macular thickness, and fluorescein …Author: George A. Williams, Julia A. Haller, Baruch D. Kuppermann, Mark S. Blumenkranz, David V. Weinberg, C...
https://www.ncbi.nlm.nih.gov/pubmed/31040133
Posterior segment drug delivery for the treatment of exudative age-related macular degeneration and diabetic macular oedema. Wong CW(1)(2), Wong TT(3)(4). Author information: (1)Surgical Retina, Singapore National Eye Centre, Singapore, Singapore.Author: Chee Wai Wong, Tina T Wong
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