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https://www.sciencedirect.com/science/article/pii/S0168365908006834
Mar 04, 2009 · siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers—but exposed positive charge is problematic in vivo.Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes.Author: Younghoon Kim, Manorama Tewari, J. David Pajerowski, Shenshen Cai, Shamik Sen, Jason Williams, Shash...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740336/
Mar 04, 2009 · siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers–but exposed positive charge is problematic in vivo.Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes.Author: Younghoon Kim, Manorama Tewari, J. David Pajerowski, Shenshen Cai, Shamik Sen, Jason Williams, Shash...
https://www.researchgate.net/publication/267354667_Polymersome_Delivery_of_siRNA_and_Antisense_Oligonucleotides
siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers but positively charged assemblies are ...
https://europepmc.org/articles/PMC2740336
Nov 12, 2008 · siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers–but exposed positive charge is problematic in vivo.Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes.Author: Younghoon Kim, Manorama Tewari, J. David Pajerowski, Shenshen Cai, Shamik Sen, Jason Williams, Shash...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://www.aiche.org/conferences/aiche-annual-meeting/2008/proceeding/paper/478c-polymersome-delivery-sirna-and-antisense-oligonucleotides
Nov 19, 2008 · siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers ? but positively charged assemblies are problematic in vivo. Here we demonstrate loading and functional delivery of RNAi and AON with neutral, nano-transforming polymersomes.
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