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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255357/
This update review is on mucoadhesive polymers used in nasal dosage forms. The nasal mucosa provides a potentially good route for systemic drug delivery. One of the most important features of the nasal route is that it avoids first-pass hepatic metabolism, thereby reducing metabolism.
https://www.sciencedirect.com/science/article/abs/pii/S0169409X05001444
Buccal delivery of the desired drug using mucoadhesive polymers has been the subject of interest since the early 1980s. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. This review highlights the use of mucoadhesive polymers in buccal drug delivery.Author: Nazila Salamat-Miller, Montakarn Chittchang, Thomas P. Johnston
https://www.tandfonline.com/doi/abs/10.1163/138577209X12478283327236
Oct 14, 2004 · The current review provides a good insight on mucoadhesive polymers, the phenomenon of mucoadhesion and the factors which have the ability to affect the mucoadhesive properties of a polymer. Polymers in Mucoadhesive Drug-Delivery Systems: A Brief Note: Designed Monomers and Polymers: Vol 12, No 6Author: S. Roy, K. Pal, A. Anis, K. Pramanik, B. Prabhakar
https://www.sciencedirect.com/science/article/pii/S0169409X05001444
Unfortunately, only a few studies have been conducted with new generation mucoadhesive polymers for buccal drug delivery. With advantages such as an increase in the residence time of the polymer, site-specific adhesion, penetration enhancement, and enzymatic inhibition, site-specific mucoadhesive polymers will undoubtedly be utilized for the buccal delivery of a wide variety of therapeutic …Author: Nazila Salamat-Miller, Montakarn Chittchang, Thomas P. Johnston
https://www.tandfonline.com/doi/pdf/10.1163/138577209X12478283327236
The use of mucoadhesive polymers for the development of pharmaceutical for-. mulations dates back to 1947, when attempts were made to formulate a penicillin. drug-delivery system for delivering the bioactive agent to the oral mucosa us-. ing gum tragacanth and dental adhesive powders [16, 17].Author: S. Roy, K. Pal, A. Anis, K. Pramanik, B. Prabhakar
https://www.researchgate.net/publication/326003441_Applications_of_natural_polymers_in_mucoadhesive_drug_delivery_An_overview
Mucodhesion refers to bond formed between two biological surfaces or a bond connecting a biological and a synthetic polymer surface. Under this drug delivery, buccal mucosa is the preferred site...
https://www.researchgate.net/publication/318159694_Mucoadhesive_Polymers_for_Drug_Delivery_Systems
The current article focuses on polymers used in mucosal delivery of therapeutic agents. The mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
This makes the buccal cavity more suitable for mucoadhesive drug delivery. The various mucoadhesive polymers used for the development of buccal delivery systems include cyanoacrylates, polyacrylic acid, sodium carboxymethylcellulose, hyaluronic acid, hydroxypropylcellulose, polycarbophil, chitosan and gellan.
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