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https://www.sciencedirect.com/science/article/pii/S0168365919306108
The chemical structures of the five amphiphiles (a–e) tested as potential polymeric gene delivery systems by Prata et al. . After incubation of the three DNA complexes in esterase at pH 7.4, the complex formed with a dissociated, releasing the DNA therapeutic, while the other two complexes remained intact.Author: Anna Kargaard, Anna Kargaard, Joost P.G. Sluijter, Bert Klumperman
https://www.sciencedirect.com/science/article/pii/S016777991830060X
Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to their lower immunogenicity and pathogenicity. However, during intracellular delivery of these carriers, multiple barriers have to be overcome or the efficiency of gene delivery will be impeded.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523186/
Apr 25, 2019 · Evaluation of functionalization strategies for therapeutic and formulation stability are also highlighted. The overview of the properties, challenges, and functionalization approaches and, finally, the applications of the polymeric delivery systems in gene therapy marks this review as a unique one-stop summary of developments in this field.Author: Raj Rai, Saniya Alwani, Ildiko Badea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178691/
Systemic gene delivery requires the rational design of a polymeric gene vehicle with high solubility, low cytotoxicity, serum stability, efficient endosomal release, adequate protection against endonucleases, and most importantly, a high transfection efficiency and gene expression.Author: Sung Wan Kim, Sung Wan Kim
https://www.crcpress.com/Polymeric-Gene-Delivery-Principles-and-Applications/Amiji/p/book/9780849319341
Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers.
https://pubs.acs.org/doi/10.1021/bm034041%2B
Nov 21, 2003 · One of the crucial steps in gene delivery with cationic polymers is the escape of the polymer/DNA complexes (“polyplexes”) from the endosome. A possible way to enhance endosomal escape is the use of cationic polymers with a pKa around …Author: Arjen M. Funhoff, Cornelus F. Van Nostrum, Gerben A. Koning, Nancy M. E. Schuurmans-Nieuwenbroek, Da...
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Dash, P. R. et al. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.201900213
Polymeric Nonviral Gene Delivery Systems for Cancer Immunotherapy. Lingjie Ke. Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102 China.Author: Lingjie Ke, Pingqiang Cai, Yun‐Long Wu, Xiaodong Chen
https://www.researchgate.net/publication/268038834_Polymeric_Nanocarriers_for_Non-Viral_Gene_Delivery
Gene therapy holds great promise for the treatment of acquired and inherited diseases. Non-viral gene delivery systems are gaining recognition as alternatives to viral gene vectors due to their ...
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
Polymeric Nanoparticles for Gene Delivery. The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular ...
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