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Polymer Nanoparticle for Oral Anticancer Drug Delivery One of the problems that cancer patients face is that many of the most potent anticancer therapies can be administered only by injection, which means that cancer patients must travel to receive their medication.
https://www.nanowerk.com/news/newsid=8934.php
Jan 16, 2009 · Polymer nanoparticle for oral anticancer drug delivery (Nanowerk News) One of the problems that cancer patients face is that many of the most potent anticancer therapies can be administered only by injection, which means that cancer patients must travel to receive their medication. But thanks to a new type of nanoparticle developed by researchers at the Johns Hopkins University School of Medicine, future cancer patients may be able to receive their medication in pill …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322271/
May 01, 2012 · Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. Drug delivery must overcome numerous ...Author: Laura M. Ensign, Laura M. Ensign, Richard Cone, Richard Cone, Justin Hanes
https://pubs.rsc.org/en/content/articlelanding/2018/nr/c8nr05933k#!
Polymer nanoparticles for the intravenous delivery of anticancer drugs: the checkpoints on the road from the synthesis to clinical translation. Abstract. In this review article we discuss some of the key aspects concerning the development of a polymer-based nanoparticle formulation for intravenous drug delivery.
https://pubs.acs.org/doi/abs/10.1021/am100435k
Aug 09, 2010 · We prepared a new conjugated polymer nanoparticle with the size of about 50 nm that is prepared by electrostatic assembly of cationic conjugated polymer PFO and anionic poly(l-glutamic acid) conjugated with anticancer drug doxorubicin (PFO/PG-Dox). The PFO exhibits good fluorescence quantum yield, photostability, and little cytotoxicity to meet the essential requests for cell imaging. In …Author: Xuli Feng, Fengting Lv, Libing Liu, Hongwei Tang, Chengfen Xing, Qiong Yang, Shu Wang
https://pubs.acs.org/doi/10.1021/bm060065f
Expert Opinion on Drug Delivery 2008, 5 (1) , 45-68. DOI: 10.1517/17425247.5.1.45. Camile B Woitiski, Rui A Carvalho, António J Ribeiro, Ronald J Neufeld, Francisco Veiga. Strategies Toward the Improved Oral Delivery of Insulin Nanoparticles via Gastrointestinal Uptake and Translocation.Author: Feng Qian, Fuying Cui, Jieying Ding, Cui Tang, Chunhua Yin
https://www.researchgate.net/publication/41850553_Polymeric_Nanoparticles_for_Drug_Delivery
Nanoparticles are being developed for in vivo tumor imaging, targeted drug delivery and biomolecular profiling of cancer biomarkers. Biodegradable polymeric nanoparticles (NPs) have been shown promissory as controlled drug delivery systems, showing high therapeutic potential [3].
https://www.sciencedirect.com/topics/materials-science/polymer-nanoparticles
Polymeric nanoparticles can also be made from synthetic polymers. Synthetic polymers can be of two types: biodegradable and nonbiodegradable. Poly (d,l-lactic-co-glycolic acid) (PLGA) is a biodegradable polymer and PLGA has been used for the transdermal delivery of indomethacin, Spantide II, and ketoprofen [259,260].
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Graphene-based polyurethane nanohybrids have been prepared by grafting long chain polyurethane onto the surface of functionalized graphene oxide for sustained drug delivery of an anticancer drug ...Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
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