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https://www.researchgate.net/publication/5993611_Polymer_Implants_for_Intratumoral_Drug_Delivery_and_Cancer_Therapy
Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy Article · Literature Review in Journal of Pharmaceutical Sciences 97(5):1681-702 · May 2008 with 202 Reads How we measure 'reads'
https://www.researchgate.net/publication/11852802_Biodegradable_polymer_implants_to_treat_brain_tumors
Biodegradable polymer implants to treat brain tumors. ... We demonstrated the feasibility of polymer-mediated drug delivery by using the standard chemotherapeutic agent 1,3-bis(2-chloroethyl)-1 ...
https://www.nature.com/articles/srep43271
Direct drug delivery into the brain using polymeric implants 18,19,20, microparticles 21, microcapsules 22, microchips 23 and nanoparticles 24,25 has been an important topic of GBM research ...
https://www.mdpi.com/journal/polymers/special_issues/drug-delivery
Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable implants ensure long-term delivery…
https://link.springer.com/chapter/10.1007/978-3-642-03887-7_4
Polymer has received a growing attention as a material for drug delivery systems (DDS), especially brain cancer because of its biodegradable and biocompatible properties. Ease of polymer synthesis makes it possible to tune polymer properties to provide different drug …
https://www.nature.com/articles/s41467-019-13198-y
Nov 15, 2019 · We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch …
https://jhu.pure.elsevier.com/en/publications/biodegradable-polymer-implants-to-treat-brain-tumors-3
We have developed a systematic approach for the discovery and evaluation of local treatment strategies for brain tumors using polymers. We demonstrated the feasibility of polymer-mediated drug delivery by using the standard chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and showed that local treatment of gliomas by this method is effective in animal models of intracranial ...
https://www.liebertpub.com/doi/10.1089/sct.1989.5.55
Apr 02, 2009 · Chemotherapy for brain tumors with polymer drug delivery. Enzyme-Promoted Degradation of Polymeric Matrices for Controlled Drug Delivery: Analytical Model and Numerical Simulations. ... Polymer implants for drug delivery in the brain…
https://thejns.org/view/journals/j-neurosurg/74/3/article-p441.xml
Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. Henry Brem M.D. 1 , ... Implantation of the drug-impregnated polymer at the tumor site allows prolonged local exposure with minimal systemic exposure. ... Controlled-release polymer systems for drug delivery to the brain. Polymer Preprints 31: 229 1990 ...
https://www.pharmatutor.org/articles/review-implantable-drug-delivery-system
Therefore, drug delivery systems were developed to optimize the therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery …
https://file.scirp.org/pdf/JBM_2016011414462012.pdf
Polymer drug conjugates such as Zoladex, Lupron Depot, On Caspar PEG intron are used in treatment of prostate cancer and lymphoblastic leukemia. Polymeric Drug Delivery systems are being utilized for controlled drug delivery assuring patient compliance. Keywords Polymeric Drug Delivery, Biocompatible Polymers, Smart Polymers, Polymeric Implants,
https://www.future-science.com/doi/10.4155/tde-2017-0082
The present review discusses different type of implantable systems such as solid implants, in situ forming implants, in situ forming microparticles, depot formulations, polymeric-lipid implants, sucrose acetate isobutyrate and N-stearoyl L-alanine methyl ester systems for continuous drug delivery into brain for various brain diseases including ...
https://journals.sagepub.com/doi/10.1177/153303460500400409
This review discusses the rationale for local drug delivery, describes the development of currently available polymer-based therapeutic agents, and highlights examples of promising non-polymer based drug delivery methods for use in the treatment of malignant brain tumors.
https://jhu.pure.elsevier.com/en/publications/interstitial-chemotherapy-with-drug-polymer-implants-for-the-trea-4
title = "Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas", abstract = "Malignant gliomas have been difficult to treat with chemotherapy. The most effective agent, BCNU (carmustine), has considerable systemic toxicity and a short half-life in serum.
https://pdfs.semanticscholar.org/d9ec/25acebcd1db49cb471210fea3f1644cb30f9.pdf
both drug delivery and medical device applications. The manufacturing process for the Atrigel® system is not polymer into a biocompatible solvent. The drug is next added to the solution where it dissolves or forms a suspension. This drug/ polymer mixture is then easily and conveniently injected into the body where it forms a solid
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