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https://www.pnas.org/content/98/3/1200
Jan 30, 2001 · Cytotoxic gene-delivery systems may compromise these processes and limit protein expression. This situation is perhaps most prevalent in current nonviral polycationic gene-delivery systems in which the polycationic nature of the delivery system can lead to cytotoxicity.Author: David Putnam, Christine A. Gentry, Daniel W. Pack, Robert Langer
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties. These polymers can be conjugated with genetic material via electrostatic attraction at physiological pH, thereby facilitating gene delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · The gene delivery system based on polysaccharide indicates that the structure of the cationic polysaccharide has a significant role in the transfection activity for gene delivery. The colloidal polysaccharide particles had investigated for the mucosal delivery of complexes such as peptides, proteins, oligonucleotides, and plasmids [ 69 ].Author: YK Sung, SW Kim
https://www.researchgate.net/publication/289718261_Polymer-Based_Gene_Delivery_Systems
In conclusion, cationic polymers appear to be the more stable gene delivery systems for topical application into the airways. View Show abstract Zou, SM, Erbacher, P, Remy, JS and Behr, JP.
https://www.researchgate.net/publication/23317410_Polymer-Based_Gene_Delivery_A_Current_Review_on_the_Uptake_and_Intracellular_Trafficking_of_Polyplexes
Lipoplexes and polyplexes, electrostatic complexes between a plasmid DNA and cationic lipids or polymers are chemical systems that are developed for gene delivery.
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro.Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
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