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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/polyethyleneimine
Cationic polymers such as polyethyleneimine (PEI), dendrimers, chitosan, and poly(Lys) are polyplexes that have been studied for gene delivery. However, whereas most of these cationic polymers have transfection ability, they also have a relatively higher cytotoxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853266/
Sep 15, 2005 · Polyethyleneimine (PEI) has been used previously as a nonviral DNA transfer vector. In this article, we demonstrate its use as a vehicle for transmembrane delivery of proteins in cell culture conditions. Linking proteins to PEI required no other treatment beyond mixing them with PEI.Author: V. V. Didenko, H. Ngo, David S. Baskin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848998/
In this study, we generated a cationic polyethyleneimine (PEI)-modified gelatin nanoparticle and evaluated its intracellular protein delivery ability in vitro and in vivo. The experimental results showed that the PEI-modified gelatin nanoparticle had a zeta potential of approximately +60 mV and the particle size was approximately 135 nm.Author: Ming Ju Chou, Hsing Yi Yu, Jui Ching Hsia, Ying Hou Chen, Tzu Ting Hung, Hsiao Mei Chao, Edward Cher...
https://www.mdpi.com/1996-1944/11/2/301/pdf
efficient intracellular functional protein delivery would be beneficial for protein drug discovery. In this study, we generated a cationic polyethyleneimine (PEI)-modified gelatin nanoparticle and evaluated its intracellular protein delivery ability in vitro and in vivo.Author: Ming Ju Chou, Hsing Yi Yu, Jui Ching Hsia, Ying Hou Chen, Tzu Ting Hung, Hsiao Mei Chao, Edward Cher...
https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-46
Apr 23, 2011 · The FA-PEAs probably provide a potential gene delivery system to treat RCC even other cancers in future. Polyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted to use as a gene delivery …Author: Zhizhong Xu, Guobo Shen, Xiangying Xia, Xinyu Zhao, Peng Zhang, Huanhuan Wu, Qingfa Guo, Zhiyong Qia...
https://www.mdpi.com/1996-1944/11/2/301/htm
Intracellular protein delivery may provide a safe and non-genome integrated strategy for targeting abnormal or specific cells for applications in cell reprogramming therapy. Thus, highly efficient intracellular functional protein delivery would be beneficial for protein drug discovery. In this study, we generated a cationic polyethyleneimine (PEI)-modified gelatin nanoparticle and evaluated ...Author: Ming Ju Chou, Hsing Yi Yu, Jui Ching Hsia, Ying Hou Chen, Tzu Ting Hung, Hsiao Mei Chao, Edward Cher...
https://www.nature.com/articles/3302050
Aug 18, 2003 · Polyethylenimine (PEI), a polycation with high ionic charge density, has recently been used as a gene therapy delivery agent. We have defined the optimal conditions for PEI-based transfection of airway epithelial cells in vitro and in vivo and used these conditions to restore Cl − channel activity in a CF mouse model.Author: J W Wiseman, C A Goddard, D McLelland, W H Colledge
https://www.nature.com/articles/3300471
Aug 01, 1997 · Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery. Abstract. A simple and inexpensive method of condensing and linking plasmid DNA to carrier adenovirus particles is described.Author: A Baker, M Saltik, H Lehrmann, I Killisch, V Mautner, G Lamm, G Christofori, M Cotten
https://en.wikipedia.org/wiki/Polyethylenimine
Polyethylenimine (PEI) or polyaziridine is a polymer with repeating unit composed of the amine group and two carbon aliphatic CH 2CH 2 spacer. Linear polyethyleneimines contain all secondary amines, in contrast to branched PEIs which contain primary, secondary and tertiary amino groups.Chemical formula: (C₂H₅N)ₙ, linear form
https://www.thno.org/v09p3280.htm
Protein delivery was optimized through fluorescent conjugation and confocal microscopy analysis, achieving up to ~90% delivery in the cytosol and nucleus of HeLa cells. Delivery of the active protein achieved up to ~30% gene editing efficiency of the PTEN and AAVS1 genes.
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