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https://www.ncbi.nlm.nih.gov/pubmed/10738575
METHODS: Polycation-based vectors, including adenovirus-enhanced transferrinfection (AVET) and transferrin-polyethylenimine (Tf-PEI), were tested for gene delivery into subcutaneously growing tumors after local and systemic application. DNA biodistribution and reporter gene expression was measured in the major organs and in the tumor.Author: Ralf Kircheis, Susanne Schüller, Sylvia Brunner, Manfred Ogris, Karl-Heinz Heider, Wolfgang Zauner, ...
https://www.academia.edu/20479546/Polycation-based_DNA_complexes_for_tumor-targeted_gene_delivery_in_vivo
Polycation-based DNA complexes for tumor-targeted gene delivery in vivo
https://www.sciencedirect.com/science/article/pii/S016836590300230X
DNA polyplexes based on the condensation of plasmid DNA with the cationic polymer polyethylenimine (PEI) display high transfection efficiency in cell culture and have potential for gene delivery in vivo , .Author: Manfred Ogris, Greg Walker, Thomas Blessing, Ralf Kircheis, Markus Wolschek, Ernst Wagner
https://www.sciencedirect.com/science/article/pii/S0168365901002723
May 14, 2001 · Incorporation of the receptor binding ligands transferrin (Tf) or epidermal growth factor (EGF) into DNA/polyethylenimine (PEI) complexes was found to enhance gene transfer into tumor cell lines in a receptor-dependent manner. In systemic applications, the surface charge of DNA complexes dominated the in vivo characteristics of gene transfer.Author: Ralf Kircheis, Thomas Blessing, Sylvia Brunner, Lionel Wightman, Ernst Wagner, Ernst Wagner
https://www.nature.com/articles/3301939
Apr 17, 2003 · Viral gene delivery is more efficient than nonviral delivery, but nonviral vectors like DNA/polycation complexes (polyplexes) are less immunogenic, can be …Author: I J Hildebrandt, M Iyer, E Wagner, S S Gambhir
https://www.nature.com/articles/3301351
Mar 06, 2001 · Systemic application of positively charged polycation/DNA complexes has been shown to result in predominant gene expression in the lungs. Targeting gene expression to other sites, eg distant tumors, is hampered by nonspecific interactions largely due to the positive surface charge of transfection complexes.Author: R Kircheis, L Wightman, A Schreiber, B Robitza, V Rössler, M Kursa, E Wagner
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