Poly L Lysine Drug Delivery

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Poly-L-lysine-coated nanoparticles: a potent delivery ...

    https://www.ncbi.nlm.nih.gov/pubmed/17052812
    Jan 26, 2007 · Poly-L-lysine-coated nanoparticles: a potent delivery system to enhance DNA vaccine efficacy. Minigo G(1), Scholzen A, Tang CK, Hanley JC, Kalkanidis M, Pietersz GA, Apostolopoulos V, Plebanski M. Author information: (1)Vaccine and Infectious Diseases Laboratory, The Burnet Institute incorporating the Austin Research Institute, Austin Hospital ...Author: Gabriela Minigo, Anja Scholzen, Choon K. Tang, Jennifer C. Hanley, Martha Kalkanidis, Geoffrey A. Pi...

Poly-L-lysine hydrochloride mol wt 15,000-30,000 Sigma ...

    https://www.sigmaaldrich.com/catalog/product/sigma/p2658
    L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane.

Retinal drug delivery using eyedrop preparations of poly-l ...

    https://www.sciencedirect.com/science/article/pii/S0939641112003402
    Poly- l -lysine (PLL) is a cationic polypeptide that has been used as a modifier for drug nano-carriers and has been shown to enhance the cellular uptake of drugs by increasing the permeability of various compounds,. Here, we report the application of PLL-modified liposomes to retinal drug delivery …Author: Hitoshi Sasaki, Keiichi Karasawa, Kohei Hironaka, Kohei Tahara, Yuichi Tozuka, Yuichi Tozuka, Hirofu...

Immunocompatibility and Toxicity Studies of Poly‐L‐Lysine ...

    https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.12313
    Poly‐L‐Lysine (PLL) nanocapsules are the emerging drug‐delivery vehicle for the therapeutics of targeted diseases. The study was designed for the synthesis and characterization of PLL nanocapsules and to know its immunocompatibility and toxicity behavior for in vivo drug‐delivery applications.Author: Janeesh Plakkal Ayyappan, Haider Sami, Dhanya Chandrasekharan Rajalekshmi, Sri Sivakumar, Annie Abra...

Impact of Surface Derivatization of Poly-l-lysine ...

    https://pubs.acs.org/doi/10.1021/mp070047s
    Tritium-labeled poly-l-lysine dendrimers displaying 8 or 16 surface lysines have been capped with benzene sulfonate (BS), benzene disulfonate (BDS), or succinate (Succ) groups, and the intravenous pharmacokinetics and disposition profiles of the resulting dendrimers (Lys8(BS)16, Lys16(BS)32, Lys16(BDS)32, Lys16(Succ)32) have been evaluated. Lys16(Succ)32 was rapidly removed from the …Author: Lisa Michelle Kaminskas, Benjamin James Boyd, Peter Karellas, Scott Henderson, Michael Giannis, Guy ...

Bioinspired Star-Shaped Poly(l-lysine) Polypeptides ...

    https://www.ncbi.nlm.nih.gov/pubmed/29590755
    May 07, 2018 · 1. Mol Pharm. 2018 May 7;15(5):1878-1891. doi: 10.1021/acs.molpharmaceut.8b00044. Epub 2018 Apr 6. Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells.Author: David P. Walsh, David P. Walsh, Robert D. Murphy, Angela Panarella, Rosanne M. Raftery, Rosanne M. R...

Poly-L-lysine hydrobromide mol wt 150,000-300,000 Sigma ...

    https://www.sigmaaldrich.com/catalog/product/sigma/p1399
    Poly-L-lysine polymers can be used in promoting cell adhesion to solid substrates, conjugation to methotrexate for increased drug transport, microencapsulation of islets, cell microencapsulation technology, microarray glass slide coating, and chromosomal preparations.

Lysine Uses, Side Effects & Warnings - Drugs.com

    https://www.drugs.com/mtm/lysine.html
    Jul 24, 2019 · Lysine is an amino acid (building block of protein), and it is also known as L-2,6-diaminohexanoic acid, Lisina, Lys, Lysine Hydrochloride, Lysine Monohydrochloride, and other names. Lysine has been used in alternative medicine as a possibly effective aid in treating cold sores due to herpes simplex.9.2/10

Cationic Poly-l-lysine Dendrimers: Pharmacokinetics ...

    https://pubs.acs.org/doi/10.1021/mp060032e
    Cationic poly-l-lysine 3 H-dendrimers with either 16 or 32 surface amine groups (BHALys [Lys] 4 [3 H-Lys] 8 [NH 2] 16 and BHALys [Lys] 8 [3 H-Lys] 16 [NH 2] 32, generation 3 and 4, respectively) have been synthesized and their pharmacokinetics and biodistribution investigated after intravenous administration to rats.The species in plasma with which radiolabel was associated was also ...Author: Benjamin James Boyd, Lisa Michelle Kaminskas, Peter Karellas, Guy Yeoman Krippner, Romina Lessene, C...

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