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https://www.researchgate.net/publication/308923525_Mechanical_properties_of_PNIPAM_based_hydrogels_A_review
Among these approaches, the stimulus‐responsive hydrogel for topical drug delivery has gained increasing attention because of its prolonged drug retention at the local site and enhanced ocular ...
https://www.researchgate.net/post/Why_there_is_no_PNIPAM_based_drug_delivery_system_being_developed_yet
Why there is no PNIPAM based drug delivery system being developed yet? ... This polymer, can be used to form a hydrogel for different aims including drug delivery and targeting.
https://www.mdpi.com/2073-4360/12/3/580/htm
PNIPAM-based hydrogels have found applications in a vast range of fields, and a specific application will have particular requirements for the properties of the hydrogel. This review focuses on biomedical applications of the PNIPAM-based hydrogels in the areas of drug delivery, tissue engineering and wound dressings.
https://www.researchgate.net/publication/301646527_Snapshot_of_phase_transition_in_thermoresponsive_hydrogel_PNIPAM_Role_in_drug_delivery_and_tissue_engineering
The role of poly(N-isopropylacrylamide) (PNIPAM) hydrogels in drug delivery. (a) PNIPAM hydrogel realeases the drug upon change in temperature (b) Biodegradable PNIPAM can be prepared by ...
https://jbioleng.biomedcentral.com/articles/10.1186/s13036-020-0227-7
In the next section of the present review paper, the application of the alginate hydrogels will be defined as drug delivery vehicles for chemotherapeutic agents. The recent advances in the application of the alginate-based hydrogels will be describe later as a wound dressing and bioink in 3D bioprinting. ... PNIPAM hydrogel promotes coil to ...
https://www.nature.com/articles/s41598-018-35914-2
This behavior is driven by the swelling/shrinking processes which occur in the hydrogel when the temperature is changed, which makes it suitable for use in drug delivery systems. An important ...
http://web.ics.purdue.edu/~jfleary/nanomedicine_course_2011/Lecture_6/Lecture%206%20References/Schmaljohann%202006.pdf
drug delivery as therapeutic agent. Polymers show usually an improved pharmacokinetics compared to small molecule drugs with longer circulation time and the potential for tissue targeting. Synthetic polymers are being used as drug delivery systems as a polymeric drug itself or …
https://ijpsr.com/bft-article/dual-stimuli-responsive-poly-n-isopropylacrylamide-co-acrylic-acid-copolymers-and-their-applications-in-ibuprofen-delivery/?view=fulltext
INTRODUCTION: In the past decades, environmental sensitive polymers have drawn more and more attention in drug delivery systems due to their excellent response to external stimuli changes, especially, pH 1 and temperature 2, in which poly (N-isopropylacrylamide) (PNIPAM) with thermo sensitivity has a low critical solution temperature (LCST) in aqueous solution 3 because the hydrogen bonding ...
https://www.sigmaaldrich.com/materials-science/polymer-science/nipam-polymers.html
Applications of Stimuli-responsive Polymers. The unique properties of stimuli sensitive polymers find several applications in chemical and biological processes such as controlled and self-regulated drug delivery, bio-conjugation, tissue engineering, biosensors, bio-separation etc.
https://pubs.acs.org/doi/10.1021/bm100046n
Thermoreversible hydrogels are promising matrices for tissue-engineered cartilage and spine constructs. They require specific properties during all the stages of a cell therapy (e.g., cell expansion, recovery, injection, delivery). Thermoreversible hyaluronan-poly(N-isopropylacrylamide) (HA-PNIPAM) hydrogels with well-defined molecular architecture and properties were synthesized through RAFT ...
https://www.nature.com/articles/natrevmats201671
Oct 18, 2016 · Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide …
https://en.wikipedia.org/wiki/Poly(N-isopropylacrylamide)
Poly(N-isopropylacrylamide) (variously abbreviated PNIPA, PNIPAAm, NIPA, PNIPAA or PNIPAm) is a temperature-responsive polymer that was first synthesized in the 1950s.It can be synthesized from N-isopropylacrylamide which is commercially available.It is synthesized via free-radical polymerization and is readily functionalized making it useful in a variety of applications.
https://www.hindawi.com/journals/ijps/2019/3160732/
In recent years, drug delivery systems capable of controlled dosage delivery for extended periods in the affected area have been vigorously developed all over the world . An effective drug delivery system has three critical requirements of the structure: a region for drug storage, a controlled release rate, and a release drive . Hydrogels ...
https://www.onlinelibrary.wiley.com/doi/full/10.1002/pola.24141
The hydrogels exhibited temperature or pH stimulus‐responsive behavior in water, with rapid response, high swelling ratio, and reproducible swelling/shrinkage cycles. The loading and release of ceftriaxone sodium proved the feasibility of the hydrogels as the stimulus‐responsive drug delivery system.
https://www.thefreelibrary.com/PNIPAM+Poly+(N-isopropylacrylamide)%3A+a+thermoresponsive+%22smart%22...-a0299062134
In addition, PNIPAM based hydrogels can be utilized for photodynamic therapy and drug delivery driven photo-thermally. In such cases, photosensitive moieties are attached to PNIPAM hydrogels and volume transitions are achieved by irradiating the entire system at the resonance wavelength of the photosensitive moieties.
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