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https://www.hcs.harvard.edu/~jus/england.pdf
mediately suits it to protein drug Stabilization and Release Effects of Pluronic F127 in Protein Drug Delivery Jeremy L. England This paper explores the biochemistry of the surfactant hydrogel Pluronic F127 in its capacity as a protein drug delivery mechanism. Computer modeling techniques were used to simulate the behavior
https://www.sciencedirect.com/science/article/pii/S037851731630120X
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering.Author: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhyp...
https://www.sciencedirect.com/science/article/pii/S0021979719315632
Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Author links open overlay panel Bana Shriky a Adrian Kelly a Mohammad Isreb b Maksims Babenko a Najet Mahmoudi c Sarah Rogers c Olga Shebanova d Tim Snow d Tim Gough a. Show more.Author: Bana Shriky, Adrian Kelly, Mohammad Isreb, Maksims Babenko, Najet Mahmoudi, Sarah Rogers, Olga Sheba...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075891/
Jan 19, 2011 · MTT assay and drug uptake studies showed that the treatment with PTX-loaded liposomal 18% Pluronic F127 yielded cytotoxicities, intercellular fluorescence intensity, and drug concentration in KB cells much higher than that of conventional liposome, while blank liposomal 18% Pluronic F127 gel was far less than the Cremophor EL ® vehicle and ...Author: Shufang Nie, WL Wendy Hsiao, Weisan Pan, Zhijun Yang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678942/
Sep 10, 2008 · Biological activity of Pluronic molecules. The polymers used for drug delivery were considered as biologically inert components that protect drugs from degradation, prolong exposure of drugs to tissues, and enhance transport of drugs into cells.Author: Elena V. Batrakova, Alexander V. Kabanov, Alexander V. Kabanov
https://www.nature.com/articles/srep42465
For the intracellular co-delivery of Pluronic L61 unimers and curcumin in MDR cells, endosomal pH (pH ~5.5)-sensitive micelles conjugated with folate (F-pHSM) were constructed using a copolymer ...Author: Wei Hong, Hong Shi, Hong Shi, Mingxi Qiao, Zehui Zhang, Wenting Yang, Lingying Dong, Fucheng Xie, Ch...
http://www.nanomedicine-rj.com/article_33841_b1576cc2aee92abcb722689d25e18a71.pdf
drug solubility and increased the circulation time in blood compound to the corresponding naked drug and provided platform for multidrug delivery and theranostics [30]. The using of pluronic® as drug delivery system are not only recent but also, the mixture of the doxorubicin as an anticancer drug (DOX) whit of pluronic® L61 and F127 micellesAuthor: Abbas Rahdar, Susan kazemi, Faezeh Askari
https://www.nature.com/articles/s41598-017-03123-y
Jun 07, 2017 · A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the ...Author: Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen
https://cpb-us-e1.wpmucdn.com/you.stonybrook.edu/dist/f/2071/files/2017/04/1-Kim-F127-Pg-9-19-y289nt.pdf
Pluronic F127 is a unique hydrogel due to its sol-gel transition properties determined by temperature and concentration. By investigating its rheological properties and drug release capability, F127 can be used as a drug delivery system for the spinal column. In this study,
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-9-8
Feb 11, 2009 · Most conventional methods for delivering chemotherapeutic agents fail to achieve therapeutic concentrations of drugs, despite reaching toxic systemic levels. Novel controlled drug delivery systems are designed to deliver drugs at predetermined rates for predefined periods at the target organ and overcome the shortcomings of conventional drug formulations therefore could diminish the side ...Author: Chang Yang Gong, Shuai Shi, Peng Wei Dong, Xiu Ling Zheng, Shao Zhi Fu, Gang Guo, Jing Liang Yang, Y...
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