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https://www.sciencedirect.com/science/article/pii/S0939641104000475
PLGA–PEI nanoparticles for gene delivery to pulmonary epithelium. ... Pulmonary gene delivery is thought to play an important role in treating genetically related diseases and may induce immunity towards pathogens entering the body via the airways. ... Since PLGA–PEI nanoparticles delivered the DNA into the cells, escaped the endo-lysosmal ...Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.researchgate.net/publication/8499687_PLGA-PEI_nanoparticles_for_gene_delivery_to_pulmonary_epithelium
PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium Article in European Journal of Pharmaceutics and Biopharmaceutics 58(1):1-6 · August 2004 with 188 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/abs/pii/S0939641104000475
Cytotoxicity of these nanoparticles was dependent on the PEI–DNA ratio and best cell viability was achieved by PEI–DNA ratios 1:1 and 0.5:1. These findings demonstrate that PLGA–PEI nanoparticles are a potential new delivery system to carry genes to the lung epithelium.Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008694/
Polymeric nanoparticles (NPs) are promising carriers of biological agents to lung due to advantages including biocompatibility, ease of surface modification, localized action and reduced systemic toxicity. ... Borchard G. PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium. Eur J Pharm Biopharm. 2004; 58:1 ... Sorrentino R ...Author: Jyothi U. Menon, Jyothi U. Menon, Priya Ravikumar, Amruta Pise, Amruta Pise, Dipendra Gyawali, Dipen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660441/
Feb 09, 2009 · Gene silencing using small interfering RNA (siRNA) has several potential therapeutic applications. In the present study, we investigated nanoparticles formulated using the biodegradable polymer, poly(d, l-lactide-co-glycolide) (PLGA) for siRNA delivery.A cationic polymer, polyethylenimine (PEI), was incorporated in the PLGA matrix to improve siRNA encapsulation in PLGA nanoparticles.Author: Yogesh Patil, Yogesh Patil, Jayanth Panyam
https://link.springer.com/article/10.1007%2Fs12010-017-2434-3
Feb 24, 2017 · Search SpringerLink. ... and Biotechnology. September 2017, Volume 183, Issue 1, pp 126–136 Cite as. Co-delivery of Doxorubicin Encapsulated PLGA Nanoparticles and Bcl-xL shRNA Using Alkyl-Modified PEI into Breast Cancer Cells ... S., Junginger, H. E., & Borchard, G. (2004). PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium ...Author: Mahboubeh Ebrahimian, Mahboubeh Ebrahimian, Sahar Taghavi, Ahad Mokhtarzadeh, Mohammad Ramezani, Mar...
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