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https://www.sciencedirect.com/science/article/pii/S1549963409001920
In general, ocular efficacy is closely related to ocular drug bioavailability, which may be enhanced by increasing corneal drug penetration and prolonging precorneal drug residence time. 3 A variety of ocular drug delivery systems such as inserts 4 and collagen shields 5 and colloidal systems such as liposomes,6, 7 nano-particles,3, 8 and ...Author: Himanshu Gupta, Himanshu Gupta, Mohammed Aqil, Roop K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mitt...
http://www.nanovexbiotech.com/plga-nanoparticles-ocular-drug-delivery/
Nov 14, 2017 · PLGA nanoparticles in the ocular drug delivery The topical ocular administration of drugs has two different purposes: to treat superficial eye diseases, such as infections (e.g. conjunctivitis, blepharitis, keratitis sicca) and to provide intraocular treatment through the cornea for diseases such as glaucoma or uveitis.Compared with drug delivery to other parts of the body, ocular …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347861/
Sep 01, 2011 · In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications.PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer.Author: Hirenkumar K. Makadia, Steven J. Siegel
https://www.sciencedirect.com/science/article/pii/S0022354916328106
PLGA nanospheres for the ocular delivery of flurbiprofen: Drug release and interactions. ... The use of colloidal drug delivery systems, for example, ... This study evaluated the suitability and feasibility of PLGA NEs as an ocular FB delivery system. The size and spherical morphology of the NEs prepared was suitable for ophthalmic administration.Author: E. Vega, F. Gamisans, M.L. García, A. Chauvet, F. Lacoulonche, M.A. Egea
https://www.ondrugdelivery.com/ocular-drug-delivery-technologies-exciting-times-ahead/
Nevertheless, novel ocular drug delivery technologies offer great market potential and it is certainly a very exciting area to be working in at the present time. REFERENCES. O’Rourke M, “Next Generation Ocular Drug Delivery Platforms”. Eye on Innovation, The Official Publication of OIS, 2014, Vol 1, p 7.
https://doylegroup.mit.edu/sites/default/files/documents/Ding_199.pdf
Design of Mucoadhesive PLGA Microparticles for Ocular Drug Delivery Dawei Ding,† Binu Kundukad,† Ambika Somasundar,‡ Sindhu Vijayan,§ Saif A. Khan,*,†,‡ and Patrick S. Doyle*,†,∥ †BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, 1 CREATE Way, Enterprise Wing, Singapore 138602, Singapore
https://www.tandfonline.com/doi/abs/10.3109/03639041003680826
Sep 01, 2016 · Conclusion: These results suggest that the PLGA–PEG–PLGA copolymer is potential thermosensitive in situ gel-forming material for ocular drug delivery, and it may improve the bioavailability, efficacy of some eye drugs.Author: Yuan Gao, Yan Sun, Fuzheng Ren, Shen Gao
https://www.researchgate.net/publication/235924442_OCULAR_DRUG_DELIVERY_A_REVIEW
OCULAR DRUG DELIVERY: A REVIEW ... using Soluplus® can be a potential nanomedicine for ocular delivery of poorly water-soluble FML. ... the cationically modified PLGA nanoreservoir systems of ...
https://www.nature.com/articles/s41467-018-06981-w
Nov 06, 2018 · PLGA has been used in conventional intraocular implants for sustained ocular drug delivery (e.g. ozurdex, a dexamethasone-loaded PLGA-based intravitreal implant) 47.Author: Aung Than, Chenghao Liu, Hao Chang, Phan Khanh Duong, Chui Ming Gemmy Cheung, Chenjie Xu, Xiaomeng W...
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