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https://www.sciencedirect.com/science/article/pii/S0142961211011379
We have developed PLGA-based nanoparticles that provide targeted and efficient delivery of siRNA. These nanoparticles are truly multifunctional and offer several advantages over other technologies for siRNA delivery. First, PLGA, the major biomaterial used in this nanoparticle synthesis, has been safely used in clinical applications for many ...Author: Jiangbing Zhou, Toral R. Patel, Michael Fu, James P. Bertram, W. Mark Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660441/
Feb 09, 2009 · Gene silencing using small interfering RNA (siRNA) has several potential therapeutic applications. In the present study, we investigated nanoparticles formulated using the biodegradable polymer, poly(d, l-lactide-co-glycolide) (PLGA) for siRNA delivery.A cationic polymer, polyethylenimine (PEI), was incorporated in the PLGA matrix to improve siRNA encapsulation in PLGA nanoparticles.Author: Yogesh Patil, Yogesh Patil, Jayanth Panyam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204797/
We have developed PLGA-based nanoparticles that provide targeted and efficient delivery of siRNA. These nanoparticles are truly multifunctional and offer several advantages over other technologies for siRNA delivery. First, PLGA, the major biomaterial used in this nanoparticle synthesis, has been safely used in clinical applications for many ...Author: Jiangbing Zhou, Toral R. Patel, Michael Fu, James P. Bertram, W. Mark Saltzman
https://pubs.acs.org/doi/abs/10.1021/nn300106t
Composite nanofibers of biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.Author: Menglin Chen, Shan Gao, Mingdong Dong, Jie Song, Chuanxu Yang, Kenneth Alan Howard, Jørgen Kjems, Fl...
https://www.sciencedirect.com/science/article/pii/S016836591001000X
The cationic siRNA–PLGA/LPEI micelles showed superior intracellular uptake and enhanced gene silencing effect, compared to naked siRNA/LPEI complexes. The hybrid micelle structure based on siRNA and PLGA can be potentially used as an efficient siRNA delivery system for gene silencing.Author: Soo Hyeon Lee, Hyejung Mok, Yuhan Lee, Tae Gwan Park
https://www.nature.com/articles/s41598-018-25930-7
May 14, 2018 · Herein, we synthesized PLGA nanoparticles (PLGA NPs) as a co-delivery nanocarrier for MDR1 and BCL2 siRNA by using poly-L-lysine (PPL) as a …Author: Chitra Risnayanti, Chitra Risnayanti, Yeong-Su Jang, Jinju Lee, Hyung Jun Ahn
https://www.nature.com/articles/s41598-019-52142-4
Nov 01, 2019 · Preparation of siRNA loaded PLGA nanoparticles. The siRNA loaded PLGA nanoparticles were prepared by the double emulsion (water-in-oil-in-water) solvent evaporation method of …Author: Azmat Ali Khan, Amer M. Alanazi, Mumtaz Jabeen, Arun Chauhan, Mohammad Azam Ansari
https://www.researchgate.net/publication/23402893_Polymeric_Nanoparticles_for_siRNA_Delivery_and_Gene_Silencing
Polymeric Nanoparticles for siRNA Delivery and Gene Silencing Article in International Journal of Pharmaceutics 367(1-2):195-203 · November 2008 with 152 Reads How we measure 'reads'
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060860
The EGFP-EGF1-conjugated PLGA nanoparticles (ENPs) were used as a new targeted carrier for TF-specific siRNA and enabled siRNA delivery into injured primary BMECs. The physical properties of the nanoparticles, the cytotoxicity of the nanoparticles, the siRNA release in vitro from the nanoparticles, and the gene silencing effect were determined.Author: Chen Chen, Heng Mei, Wei Shi, Jun Deng, Bo Zhang, Tao Guo, Huafang Wang, Yu Hu
https://experts.umn.edu/en/publications/preparation-of-sirna-encapsulated-plga-nanoparticles-for-sustaine
Nanoparticles (NPs) formulated using poly (d,l-lactide-co-glycolide) (PLGA), a biodegradable, biocompatible, and clinically approved polymer, have been widely used for targeted drug delivery.Author: Panayotis Pantazis, Konstantinos Dimas, James H. Wyche, Shrikant Anant, Courtney W. Houchen, Jayanth...
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