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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347861/
Sep 01, 2011 · In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications.PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer.Author: Hirenkumar K. Makadia, Steven J. Siegel
https://www.ncbi.nlm.nih.gov/pubmed/28797972
Nov 01, 2017 · Multifunctional PLGA nanostructures have given an avenue to future nanomedicine to consider simultaneous drug delivery, molecular imaging, and real-time monitoring of therapeutic response. This review describes the applications of PLGA in drug delivery revealing its current progress and direction for future research.Author: Maria Mir, Naveed Ahmed, Asim ur Rehman
https://www.sigmaaldrich.com/technical-documents/articles/materials-science/plga-drug-delivery.html
Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.
https://www.sciencedirect.com/topics/neuroscience/plga
Thundiparambil Azeez Sonia, Chandra P. Sharma, in Oral Delivery of Insulin, 2014. 6.5.4 Poly(lactic-co-glycolic) acid. PLGA has been the most investigated biodegradable polymer, in part due to its approval in drug formulations and medical devices by the Food and Drug Administration (FDA) and partly due to its versatility in terms of availability of different MWs, compositions and variable ...
http://kinampark.com/PLGARef/files/Xu%202016%2C%20Polymer%20degradation%20and%20drug%20delivery%20in%20PLGA-based%20drug%E2%80%93polymer%20Applications-%20A%20review%20of%20experiments%20and%20theories.pdf
Review Article Polymer degradation and drug delivery in PLGA-based drug–polymer applications: A review of experiments and theories Yihan Xu,1 Chang-Soo Kim,1* David M. Saylor,2 Donghun Koo3* 1Materials Science and Engineering Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, 53211 2Division of Biology, Chemistry, and Materials Science, Center for Devices and …
https://www.sciencedirect.com/science/article/pii/S0378517307008630
The mobility of a drug in PLGA-based delivery systems does not only depend on its own physico-chemical properties and the type of PLGA used, but also to a large extent on the size and shape of the device. In addition, attractive ionic drug-polymer interactions can lead to unexpected low release rates.Author: D. Klose, D. Klose, F. Siepmann, K. Elkharraz, J. Siepmann, J. Siepmann
https://www.researchgate.net/publication/270765946_PLGA_A_unique_polymer_for_drug_delivery
PLGA: A unique polymer for drug delivery. ... A wide range of PLGA-based drug delivery systems have been reported for the treatment or diagnosis of various diseases and disorders. The present ...
https://www.sigmaaldrich.com/technical-documents/articles/technology-spotlights/degradex-microspheres-nanoparticles.html
Degradex ® PLGA Particles. Degradex ® PLGA microspheres and nanoparticles are polymeric particles in the size range of nanometers to microns. Both plain and fluorescently dyed particles are available. Plain PLGA microspheres and nanoparticles can be used in drug delivery research and formulation as control agents or can be used to test system compatibility before loading an API into the carrier.
https://www.researchgate.net/publication/326953261_Dual_drug_delivery_of_sorafenib_and_doxorubicin_from_PLGA_and_PEG-PLGA_polymeric_nanoparticles
Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a challenge for researchers. Here, we report the efficient entrapment of two clinically used single ...
https://drug-dev.com/microfluidic-encapsulation-controlling-drug-delivery-with-plga/
An example of this is PLGA nanostructures that combine drug delivery, molecular imaging, and real-time monitoring of therapeutic response, which are paving the way for nanomedicine in the future. The use of PLGA and microfluidics is showing tremendous promise in drug delivery, and it will be exciting to see how this technology continues to grow.
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