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https://www.researchgate.net/publication/49601002_Nasal_drug_delivery_system_-_an_overview
Nasal drug delivery system - an overview. ... Many drug delivery devices for nasal application of liquid, semisolid and solid formulation are investigated to deliver the drugs to the treat most ...
https://www.sciencedirect.com/science/article/pii/S0169409X97000586
In studying drug absorption from the nasal mucous membrane, it is essential to have a clear understanding of anatomy and physiology of the nose, and how it relates to the characteristics of the delivery system used.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649785/
Nasal cavity has been used from ancient time as a drug delivery route to alleviate diseases and disorders. One of the ‘panchakarmas’ stated in Ayurveda is ‘nasyakarma’, a practice in which a drug is administered through the nostrils[].Nasal cavity is an excellent doorway for the entry of the drug moiety to systemic circulation and central nervous system.
http://ijpsr.com/bft-article/nasal-drug-delivery-an-overview/?view=fulltext
ABSTRACT: Over the past few decades the nasal route has gained widespread interest as a promising and an alternative route to oral and parenteral drug delivery.The nasal mucosa being highly vascularized and permeable provides a rapid onset of therapeutic action. It is a convenient, compliant and needleless mode of drug delivery suitable for the treatment of both acute and chronic diseases.
http://www.authorstream.com/Presentation/ashanibasu-1975673-nasal-drug-delivery-system/
Nasal Drug Delivery System - authorSTREAM Presentation. PowerPoint Presentation: Avoidance of hepatic first-pass elimination Good penetration of lipophilic low molecular wt. drugs Rapid absorption and first onset of action due to large absorption surface.
https://www.optinose.com/wp-content/uploads/2012/10/Nasal-drug-delivery-devices-characteristics-and-performance-in-a-clnical-perspective-Review-Oct-2012.pdf
Nasal anatomy and physiology influencing drug delivery Regulation of nasal airflow Nasal breathing is vital for most animals and also for human neonates in the first weeks of life. The nose is the normal and preferred airway during sleep, rest, and mild exercise up to an air volume of …
https://www.researchgate.net/publication/234044763_Nose_to_Brain_Targeted_Drug_Delivery_bypassing_the_Blood-Brain_Barrier_An_overview
Anatomy and physiology of nose, key benefits offered by nasal drug delivery systems, mechanisms of drug absorption across nasal mucosa and metabolism of drugs in nasal cavity are discussed in ...
https://en.wikipedia.org/wiki/Nasal_drug_delivery
If a fast effect is desired or if the drug is extensively degraded in the gut or liver, drugs which are poorly absorbed orally can also be given by this route. Limitations with nasal systemic drug delivery. Nasal administration is primarily suitable for potent drugs since only a limited volume can be sprayed into the nasal …
https://www.nature.com/articles/srep31732
Aug 25, 2016 · Kumar, N., Gautam, M., Lochhead, J. et al. Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery.
https://management-forum.co.uk/product/details/936/nasal-drug-delivery
This seminar seeks to explore these and many other questions in the field of nasal drug delivery, while reviewing interesting new data and innovative technologies. Leading industry authorities will cover all the relevant aspects of nasal physiology, anatomy, formulation strategies, the absorption of a variety of drugs in various phases of drug ...
https://www.ondrugdelivery.com/patient-safety-key-driver-to-preservative-free-nasal-spray-development/
“Different types of preservative found in nasal sprays may have different undesirable side effects on the physiology of the nose cavity.” If we take a closer look at nasal drug products delivered through a device for chronic diseases, it mainly concerns locally acting drugs for allergic patients – i.e. nasal …
https://journals.physiology.org/doi/abs/10.1152/jappl.1988.64.1.377
The dosage form (drop or spray) and site of administration (dorsal or ventral surface of the nostril) profoundly affect the distribution and clearance of a gamma-emitting 99mTc-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) solution in dogs.
https://link.springer.com/article/10.1007%2Fs13346-012-0121-z
In addition, new opportunities in mucosal immunity via nasal vaccination as well as the elusive nose to brain uptake continue to drive innovation. To facilitate understanding of the issues involved that facilitate drug delivery in the nose, a review of nasal morphology and physiology is presented.
https://pdfs.semanticscholar.org/4f07/bf4cd9606de6ffcaf96c9f78d0b226690ba6.pdf
concentration required for action. But nose to brain drug delivery the drug directly enter into the brain. The objective of this review is to provide overview of nose on an physiological, anatomical and, barriers related to nasal drug delivery, physicochemical, biological and factors affecting nasal
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