Phage Drug Delivery

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Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572107/
    May 03, 2019 · The self-assembly of drug-loaded liposomes on M13 phage has been another PDT delivery approach using phage as a nanocarrier . Cationic liposomes were loaded with zinc phthalocyanine (ZnPc) and were assembled on M13 phage displaying eight glutamic acid residues on the p8 major coat protein, via electrostatic interactions.Author: Esen Sokullu, Hoda Soleymani Abyaneh, Marc A. Gauthier

Development of novel drug delivery systems using phage ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995314/
    May 11, 2016 · Development of novel drug delivery systems using phage display technology for clinical application of protein drugs Kazuya NAGANO *1 *2 and Yasuo TSUTSUMI *1 *2 *3 † *1 Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, …Author: Kazuya Nagano, Yasuo Tsutsumi

Bacteriophages and phage-inspired nanocarriers for ...

    https://www.sciencedirect.com/science/article/pii/S0169409X16300795
    The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and to ensure their efficient uptake. Recently a number of studies have focused on designing bio-inspired nanocarriers, such as bacteriophages, and synthetic carriers based on the bacteriophage structure.Author: Mahdi Karimi, Hamed Mirshekari, Seyed Masoud Moosavi Basri, Seyed Masoud Moosavi Basri, Sajad Bahram...

Fibrin glue as a local drug-delivery system for ...

    https://www.nature.com/articles/s41598-018-38318-4
    Feb 14, 2019 · Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery. Effective local delivery of ...Author: Evgenii Rubalskii, Stefan Ruemke, Christina Salmoukas, Andrey Aleshkin, Svetlana Bochkareva, Evgeny ...

Drug delivery to the brain: self-assembled phage mimetics ...

    https://bioengineeringcommunity.nature.com/users/316001-seyed-moein-moghimi/posts/54086-drug-delivery-to-the-brain-self-assembled-phage-mimetic-for-rapid-targeting-of-the-brain
    However, CNS drug discovery and development is a costly and highly risky business with low regulatory approval rates. A key hurdle is the blood-brain-barrier (BBB), a formidable barrier to successful delivery of many therapeutic molecules including biopharmaceuticals to the CNS.Author: Seyed Moein Moghimi

Paving the way for new peptide-based therapeutics with ...

    https://phys.org/news/2020-03-paving-peptide-based-therapeutics-method-phage.html
    Mar 19, 2020 · Phage display is one of several tools that scientist rely on to find new peptides with potential use as drugs to treat diseases, explains 2018 Texas …

Plant viruses and bacteriophages for drug delivery in ...

    https://www.sciencedirect.com/science/article/pii/S1367593116302009
    Here, we highlight the development of plant viruses and bacteriophages (i.e., viruses that infect bacteria) as an emerging class of biologics for use in drug delivery. Viruses can be regarded as natural carrier systems; they have evolved to package, protect, and deliver nucleic acid cargo to host cells.Author: Anna E Czapar, Nicole F Steinmetz

Landscape Phage-Targeted Drug Delivery to Breast Cancer Cells

    https://etd.auburn.edu/bitstream/handle/10415/2426/FAGBOHUN%20Olusegun%20DISSERTATION.pdf;sequence=2
    loaded nanocarriers can enhance drug delivery to breast cancer cells. Screening of multibillion landscape phage library can generate peptide ligands targeting cancer-specific receptors. We hypothesize that spontaneous insertion of isolated phage proteins into drug loaded nanocarriers

HIGHLIGHTS Phage display: development of nanocarriers for ...

    https://www.researchgate.net/profile/Mohammad_Khalaj-Kondori/publication/279193841_Phage_display_development_of_nanocarriers_for_targeted_drug_delivery_to_the_brain/links/558dc6e108ae47a3490bd7f6.pdf?inViewer=true&pdfJsDownload=true&disableCoverPage=true&origin=publication_detail
    NRAL RGNRATIN RSARCH June 21 ,Volume 1 ,Issue www.nrronline.org 862 Phage display: development of nanocarriers for targeted drug delivery to the brain 1 …

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