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https://www.researchgate.net/publication/50591301_PH-Sensitive_oral_insulin_delivery_systems_using_Eudragit_microspheres
PH-Sensitive oral insulin delivery systems using Eudragit microspheres Article (PDF Available) in Drug Development and Industrial Pharmacy 37(8):977-85 · March 2011 with 786 Reads
https://www.tandfonline.com/doi/abs/10.3109/03639045.2011.552908
Dec 19, 2012 · In this paper, we present in vitro and in vivo release data on pH-sensitive microspheres of Eudragit L100, Eudragit RS100 and their blend systems prepared by double emulsion-solvent evaporation technique for oral delivery of insulin. Of the three systems developed, Eudragit L100 was chosen for preclinical studies. Insulin was encapsulated and in vitro experiments performed on insulin …Author: Raghavendra C. Mundargi, Vidhya Rangaswamy, Tejraj M. Aminabhavi
http://europepmc.org/abstract/MED/21417605
Sep 01, 2011 · In this paper, we present in vitro and in vivo release data on pH-sensitive microspheres of Eudragit L100, Eudragit RS100 and their blend systems prepared by double emulsion-solvent evaporation technique for oral delivery of insulin. Of the three systems developed, Eudragit L100 was chosen for preclinical studies.Author: Raghavendra C. Mundargi, Vidhya Rangaswamy, Tejraj M. Aminabhavi
https://www.sciencedirect.com/science/article/pii/S0378517313006273
2.5. Insulin release in simulated gastrointestinal (GI) fluid. The release of insulin from the PEA blend microspheres was investigated in both simulated pH conditions of gastric fluid and intestinal fluid (Sung et al., 2012).In detail, the insulin-loaded microspheres (50 mg) were placed into 5 mL simulated gastric fluid (hydrochloric acid buffer, pH = 1.2) and incubated (37 °C, 100 rpm) for 2 h.Author: Pan He, Huaiyu Liu, Zhaohui Tang, Mingxiao Deng, Yan Yang, Xuan Pang, Xuesi Chen
https://www.researchgate.net/publication/292542659_Microspheres_as_oral_delivery_system_for_insulin
PH-Sensitive oral insulin delivery systems using Eudragit microspheres. Article. Full-text available. ... we present in vitro and in vivo release data on pH-sensitive microspheres of Eudragit L100 ...
https://www.sciencedirect.com/science/article/pii/S0169409X98000751
These results were very encouraging and many others applied similar strategies to oral insulin delivery. In another study using different polyacrylic coatings (Eudragit L100 and S100), slower release at pH 7.0 was found with the S100 capsules as compared with the L100 capsules.Author: Beth A. Burnside, Carol E. Mattes, Charlotte M. McGuinness, Edward M. Rudnic, George W. Belendiuk
https://freepaper.me/downloads/abstract/10.3109/03639045.2011.552908
pH-Sensitive oral insulin delivery systems using Eudragit microspheres. In this paper, we present in vitro and in vivo release data on pH-sensitive microspheres of Eudragit L100, Eudragit RS100 and their blend systems prepared by double emulsion-solvent evaporation technique for oral delivery of insulin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Delivery Systems for Oral Insulin Administration ... The anionic polymer Eudragit S1000 is used for intestinal delivery of drugs because of its ability to be insoluble in the stomach’s acidic ... Nanoscale analysis of protein and peptide absorption: Insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles. Eur J ...Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797490/
Formulation of insulin-loaded microspheres. Insulin microspheres were prepared according to the oil-in-oil emulsification-coacervation method using Eudragit ® RL100 polymer, which was dissolved in 12.5 mL of acetone in a 250 mL beaker with stirring at room temperature. Insulin [0.5 mL of 100 international units (IU)] and magnesium stearate (0.1 g) were dispersed in the polymer solution.
https://link.springer.com/article/10.1007/s13318-015-0261-x
Feb 05, 2015 · The aim of this work was to prepare pH-dependent clarithromycin microsphere formulation by emulsion solvent evaporation method, employing Eudragit® L-100. Prepared microspheres were evaluated by carrying out in vitro release and in vivo pharmacokinetics studies. Drug–polymer interactions were studied by differential scanning calorimetry, X-ray diffractometry analyses and results showed …Author: Jinghua Xu, Wei Li, Zhuo Liu, Jinghan Li, Xiaoyun Zhao, DongYang Li, Shuang Guo, Xiangrong Zhang
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