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https://www.sciencedirect.com/science/article/pii/S1818087614000026
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effect, easy use and better patient compliance. However, development of transdermal products is primarily hindered by the low permeability of the skin.Author: Yang Chen, Peng Quan, Xiaochang Liu, Manli Wang, Liang Fang
https://www.tandfonline.com/doi/abs/10.1081/DDC-100100984
Jul 09, 2014 · The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal (in case of side effects), and better patient compliance. However, the major limitation of this route is the difficulty of permeation of drug through the skin.Author: V. R. Sinha, Maninder Pal Kaur
https://www.tandfonline.com/doi/full/10.3109/10717544.2014.935532
Oct 10, 2008 · (2016). Permeation enhancer strategies in transdermal drug delivery. Drug Delivery: Vol. 23, Oral and Transdermal Drug Delivery, pp. 564-578.Author: Harneet Marwah, Tarun Garg, Amit K. Goyal, Goutam Rath
https://www.researchgate.net/publication/12258305_Permeation_Enhancers_for_Transdermal_Drug_Delivery
Moreover, 2% azone and 2% propylene glycol together as permeation enhancers achieved the best permeation effect for the elemene transdermal drug delivery system.
https://www.tandfonline.com/doi/abs/10.1080/17425247.2020.1713087
Transdermal drug delivery, i.e. systemic drug absorption through the skin, has several clinical benefits over oral dosage forms or injections Broader application of transdermal patches requires techniques, such as the use of permeation enhancers, to …Author: Andrej Kováčik, Monika Kopečná, Kateřina Vávrová
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.935532
advantages of transdermal drug delivery are prevention from hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Human skin surface, as a site of drug application for both local and systemic effects, is the most. eligible candidate available.
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