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https://www.sciencedirect.com/science/article/pii/S0165614702020722
Sep 01, 2002 · Coupling an amino acid residue to a drug, as with the antiviral nucleosides , appears currently to be the easiest approach to render a drug a substrate of peptide transporters. The photoactivation of endogenously accumulated porphyrins, leading to apoptosis or necrosis, is being explored for the treatment of a variety of human cancers.Author: Isabel Rubio-Aliaga, Hannelore Daniel
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(02)02072-2
Peptide transporters in other tissues, such as the brain and kidney might also contribute to drug pharmacokinetics. Research into polymorphisms in the genes that encode peptide transporters and their promoters is required to better define their role in drug delivery, deposition and renal elimination.Author: Isabel Rubio-Aliaga, Hannelore Daniel
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2037&volume=4&issue=2&spage=105
Keywords:Guanidinium, Drug Delivery, Rich Peptide Transporters. Abstract: The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters ...
https://www.ncbi.nlm.nih.gov/pubmed/12678850
Guanidinium rich peptide transporters and drug delivery. ... This review summarizes a class of transporters that have been studied and focuses on the variation and use of guanidinium based transporters to facilitate the uptake of various types of molecules into cells and tissues. Lead conjugates in this area are currently in clinical trials.Author: Lee R. Wright, Jonathan B. Rothbard, Paul A. Wender
https://www.sciencedirect.com/science/article/pii/B978190756886250006X
Peptide transporters such as PEPT1 and PEPT2 have captured most recognition in drug delivery because of its broad substrate specificity. Absorption of a diverse class of compounds such as β -lactam antibiotics, angiotensin-converting enzyme inhibitors, renin inhibitors and cephalosprorins is believed to be mediated by PEPT1 and PEPT2 ...Author: Viral Tamboli, Sujay Shah, Ashim K. Mitra
https://newsteadgroup.org/research/research/
Peptide transporters are the major route of dietary peptide absorption in the small intestine and kidneys. In humans they belong to the Solute Carrier (SLC) 15 gene family and are called PepT1 and PepT2. Both PepT1 and PepT2 are of significant pharmaceutical interest due to their ability to actively uptake a number of clinically important…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally 4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach. In the intestine, the drug should be protected from ...
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