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https://www.sciencedaily.com/releases/2019/09/190927095257.htm
Sep 27, 2019 · Scientists have developed a new method of molecular design to control both temperature reversibility and stiffness of nanofibers that are gel-forming peptides. The peptide nanofiber hydrogel can ...
https://en.wikipedia.org/wiki/Self-assembling_peptide
Self-assembling peptides are a category of peptides which undergo spontaneous assembling into ordered nanostructures.Originally described in 1993, these designer peptides have attracted interest in the field of nanotechnology for their potential for application in areas such as biomedical nanotechnology, tissue cell culturing, molecular electronics, and more.
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00309
Here we demonstrate that through manipulation of peptide primary sequence, a molecular cavity can be incorporated into the hydrophobic core of these peptide nanofibers allowing for encapsulation and delivery of small molecule drugs with poor water solubility.
https://researchportal.port.ac.uk/portal/files/7434970/Peptide_self_assemblies_for_drug_delivery.pdf
1 Peptide Self-Assemblies for Drug Delivery Diana M. Leite1, Eugen Barbu1, Geoff J. Pilkington1, Aikaterini Lalatsa1* 1Department of Pharmaceutics, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael’s Building, White Swan Road, Portsmouth PO1 2DT, UK *Corresponding author: Dr Aikaterini Lalatsa, Lecturer in Pharmaceutics, School of
https://www.hindawi.com/journals/jnm/2017/4562474/
Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery …
https://www.mdpi.com/1420-3049/24/2/351/pdf
capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery. A dual behavior is observed: on the one hand they can fulfill a structural and bioactive role. In this review, we focus on the design and the characterization of drug delivery systems using peptide-based carriers; moreover,
https://link.springer.com/article/10.1007/s12272-013-0284-2
Nov 15, 2013 · Electrospun nanofiber drug delivery systems have been studied using various techniques. Herein, we describe the fabrication of a drug-incorporating nanofiber. Drugs, such as proteins, peptide, antibodies, and small molecule drugs, can be loaded within or on the surface of nanofibers according to their properties. Hydrophobic drugs are directly dissolved with a polymer in …
https://phys.org/news/2019-09-bioactive-peptide-nanofibers-temperature-reversibility.html
Sep 27, 2019 · This method will allow the peptide nanofibers for more biomedical applicable. ... Discovery of a new vehicle peptide opens up a drug delivery route. Jun 22, …
https://cen.acs.org/articles/91/web/2013/01/Nanofibers-Help-Peptide-Drugs-Burst.html
Nanofibers Help Peptide Drugs Burst Through Blood-Brain Barrier. Drug Delivery: Peptides modified with a lipid group form tightly wrapped nanofibers that can slip into the brains of mice ...
http://www.eurekaselect.com/177957/article
Keywords:Peptide, nanomaterials, self-assembly, stimuli, mechanism, drug delivery. Abstract:Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to ...
http://www.freepatentsonline.com/y2019/0054035.html
Feb 21, 2019 · The present disclosure relates to self-assembled peptides and peptide nanostructures for use in drug delivery. BACKGROUND. Short peptide sequences for nanotechnological and nanomedicinal applications have gained popularity due to their biodegradability, simple preparation, reproducibility and ability to spontaneously form 3D structures.
https://www.researchgate.net/publication/281494592_Self-Assembling_Peptide_Nanofibrous_Hydrogel_as_a_Versatile_Drug_Delivery_Platform
Hydrogels have been widely studied in various biomedical applications, such as tissue engineering, cell culture, immunotherapy and vaccines, and drug delivery. Peptide-based nanofibers represent a ...
https://www.liebertpub.com/doi/10.1089/ten.tea.2007.0413
Nov 19, 2008 · As an approach to develop novel regenerative strategies and engineer dental tissues, two dental stem cell lines were combined with peptide-amphiphile (PA) hydrogel scaffolds. PAs self-assemble into three-dimensional networks of nanofibers, and living cells can be encapsulated.
https://www.sigmaaldrich.com/technical-documents/articles/materials-science/electrospun-nanofibers.html
Introduction. Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration. 1-3 Recently, electrospinning techniques using high-voltage electrostatic fields to generate nanofibrous structures have been used to develop drug or protein-loaded electrospun ...
https://en.wikipedia.org/wiki/Nanofibers
This adjustability is important for their application in drug delivery system in which the functional parameters need to be precisely controlled. Preliminary studies indicate that antibiotics and anticancer drugs may be encapsulated in electrospun nanofibers by adding the drug into the polymer solution prior to electrospinning.
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