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https://www.sciencedirect.com/science/article/pii/S0378517312007326
Oct 15, 2012 · Penetratin (CPP with relatively low content of basic amino acids) was functionalized to PEG–PLA nanoparticles to achieve desirable pharmacokinetic and biodistribution profiles for brain drug delivery. The obtained penetratin-NP showed a particle size of 100 nm and zeta potential of −4.42 mV.Author: Huimin Xia, Xiaoling Gao, Guangzhi Gu, Zhongyang Liu, Quanyin Hu, Yifan Tu, Qingxiang Song, Lei Yao,...
https://reference.medscape.com/medline/abstract/22841849
Nanoparticulate drug delivery system possesses distinct advantages for brain drug delivery. However, its amount that reach the brain is still not satisfied. Cell-penetrating peptides (CPPs), short peptides that facilitate cellular uptake of various molecular cargo, would be appropriate candidates for facilitating brain delivery of nanoparticles.
https://www.researchgate.net/publication/230581261_Penetratin-functionalized_PEG-PLA_nanoparticles_for_brain_drug_delivery
Penetratin (a cell-penetrating peptide with relatively low content of basic amino acids) has been functionalized to PEG-PLA NPs to achieve desirable pharmacokinetic and biodistribution profiles for...
https://www.sciencedirect.com/science/article/pii/S0142961212011994
F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery Author links open overlay panel Quanyin Hu a Guangzhi Gu a Zhongyang Liu a Mengyin Jiang d Ting Kang a Deyu Miao d Yifan Tu a Zhiqing Pang a Qingxiang Song b Lei Yao b Huimin Xia a c Hongzhan Chen b Xinguo Jiang a Xiaoling Gao b ...Author: Quanyin Hu, Guangzhi Gu, Zhongyang Liu, Mengyin Jiang, Ting Kang, Deyu Miao, Yifan Tu, Zhiqing Pang,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392984/
May 21, 2013 · In particular, the rationale of using NPs for brain drug delivery is that proper surface multifunctionalization may promote at the same time either their targeting of the BBB or the enhancement of its crossing. The possibility for BBB-impermeant drugs to reach the brain, when vehicled by NPs,...Author: Massimo Masserini
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000205/
Nov 26, 2010 · Targeted drug delivery system. PEG–PLA nanoparticles with a narrow distribution of particle size have a smaller particle size than PLA nanoparticles. Thus, they may accumulate easily in inflammation locations and then slowly release the drugs. In particular, targeting molecules can be introduced in the PEG terminal to enhance active targeting.Author: Ren Zhong Xiao, Zhao Wu Zeng, Guang Lin Zhou, Jun Jie Wang, Fan Zhu Li, An Ming Wang
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