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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171788/
Jul 03, 2018 · However, PEI was not introduced until 1995 as a multipurpose (versatile) vector for gene delivery. Gene therapy is used in different molecular weight, degree of branching, ionic strength of solution, zeta potential and different PEI particle size. PEI is a cationic polymer that is widely used in non-viral gene delivery.Author: Abbas Zakeri, Mohammad Amin Jadidi Kouhbanani, Nasrin Beheshtkhoo, Vahid Beigi, Seyyed Mojtaba Mousa...
https://www.sciencedirect.com/science/article/pii/S0928493116306634
Low molecular weight (1.8 kDa) branched polyethylenimine (PEI) has been used as non-viral vector for gene delivery because of its low toxicity, however, its further application in biomedical field has been restricted due to its low gene transfection efficiency.Author: Ming Chen, Yaqin Tang, Tingting Wang, Qipeng Long, Ziying Zeng, Houwen Chen, Xuli Feng
https://www.sciencedirect.com/science/article/pii/S0142961213013501
Polyethylenimine (PEI), a cationic polymer, has been widely studied and shown great promise as an efficient gene delivery vehicle. Likewise, the HIV-1 Tat peptide, a cell-permeable peptide, has been successfully used for intracellular gene delivery.Author: Seiichi Yamano, Jisen Dai, Shigeru Hanatani, Ken Haku, Takuto Yamanaka, Mika Ishioka, Tadahiro Takay...
https://www.sciencedirect.com/science/article/pii/S0939641104000475
Gene delivery in humans requires carriers that will transfer DNA into the nuclei of target cells. These carriers must be efficient in transfection, safe for human use, protect the DNA from degradation before arriving at the target cell and possibly hold targeting qualities for the specific delivery of the gene to the required cells or tissue.Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.sciencedirect.com/science/article/pii/B9780081005200000023
Polyethyleneimine (PEI) is a cationic polymer used as a gold standard in non-viral gene delivery. The extraordinary cationic charge and buffering capacity of the PEI has been beneficial for complexation with nucleic acids (DNA/RNA) and endosomal/lysosomal release via the so-called “proton-sponge” effect.Author: K.C. Remant Bahadur, H. Uludağ
https://www.ncbi.nlm.nih.gov/pubmed/15939236
In recent years, PEI-based non-viral vectors have been locally or systemically delivered, mostly to target gene delivery to tumor tissue, the lung or liver. This requires strategies to efficiently shield transfection polyplexes against non-specific interaction with blood components, extracellular matrix and untargeted cells and the attachment ...Author: Uta Lungwitz, Miriam Breunig, Torsten Blunk, Achim Göpferich
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