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https://www.sciencedirect.com/science/article/pii/S1359644605035750
The PEG-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents.Author: Francesco M. Veronese, Gianfranco Pasut
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,5c6300a248a5f5e1,171be91337221ac9.html
This review discusses the polymers suitable for conjugation, their conjugation methods, and their properties. Proteins and bioactive substances can be chemically modified by binding synthetic macromolecules of PEG to the surface of these biomolecules. Protein and peptide PEGylation improves the biopharmaceutical properties of drugs−that is,...
https://www.ncbi.nlm.nih.gov/pubmed/16243265
Nov 01, 2005 · The PEG-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents.Author: Francesco M. Veronese, Gianfranco Pasut
https://www.researchgate.net/publication/23638059_Jain_A_and_Jain_SK_PEGylation_an_approach_for_drug_delivery_A_review_Crit_Rev_Ther_Drug_Carrier_Syst_25_403-447
A review. Crit Rev Ther Drug Carrier Syst 25: 403-447. The current review presents an update on polyethylene glycol (PEG), which is widely used as a covalent modifier of macromolecules. This review discusses the polymers suitable for conjugation, their conjugation methods, and their properties.
https://www.researchgate.net/publication/311534729_PEGylation_successful_approach_to_drug_delivery
PEGylation based on polyethylene glycol (PEG) chains is a well-known method in drug delivery that extends the blood circulation time and delivery efficiency of nanoparticles [23, 32]. We used SPVD for conjugation with GNPs (Figure 1...
https://www.creativepegworks.com/pegylation_successful_approach_to_drug_delivery.pdf
PEGylation,successful approach to drug delivery Francesco M.Veronese and Gianfranco Pasut PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more polyethylene glycol (PEG) chains. This polymer is non-toxic, non-immunogenic, non-antigenic, highly soluble in water and FDA approved.
https://www.academia.edu/13685548/PEGylation_successful_approach_to_drug_delivery
PEGylation, successful approach to drug delivery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051498/
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune …Author: Johan J. F. Verhoef, Thomas J. Anchordoquy
https://www.nature.com/articles/nrd1033
Mar 01, 2003 · Pegylation, the process by which polyethylene glycol chains are attached to protein and peptide drugs, can overcome these and other shortcomings. By increasing the molecular mass of …Author: J. Milton Harris, Robert B. Chess
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