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https://www.path.org/publications/detail.php?i=1746
Intradermal Delivery of Vaccines: A Review of the Literature and the Potential for Development for Use in Low- and Middle-Income Countries. Produced by project Optimize and the vaccine technologies team at PATH, this report: (1) summarizes the clinical evidence supporting the intradermal route for vaccine administration and the devices being ...
https://path.azureedge.net/media/documents/TS_opt_idd_review.pdf
Intradermal Delivery of Vaccines 1. Introduction The vast majority of vaccines are delivered intramuscularly (IM) or subcutaneously (SC) using a needle and syringe (N&S). Intradermal delivery (IDD) has been and is being used as the route of choice for only a very
https://www.path.org/our-work/vaccines.php
We bring together public-and private-sector partners to advance vaccines through every stage of development—from discovery through delivery. We create ingenious technologies and strategies to help countries get them all the way to the people who need them.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044245/
Mar 01, 2011 · The recent PATH and WHO report reviewed more than 90 clinical trials of intradermal delivery with vaccines against 11 diseases. 2 For some vaccines, notably influenza and rabies vaccines, intradermal delivery of reduced doses resulted in equivalent immune responses to the standard dose delivered by the standard route.Author: JK Hickling, KR Jones, M Friede, D Zehrung, D Chen, D Kristensen
https://www.who.int/immunization/research/meetings_workshops/PDVAC_2017_Delivery_Tech_Update_Zehrung_PATH.pdf
Intradermal devices for fIPV delivery ... • DSJI needle-free method for delivery of vaccines, improving injection safety ... 2017 relabeling MCVs for Stratis® delivery (PATH/Bill & Melinda Gates Foundation supported MMR clinical study2 – noninferiority demonstrated).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173582/
The skin is known to be a highly immunogenic site for vaccination, but few vaccines in clinical use target skin largely because conventional intradermal injection is difficult and unreliable to perform. Now, a number of new or newly adapted delivery technologies ...Author: Yeu Chun Kim, Yeu Chun Kim, C Jarrahian, D Zehrung, S Mitragotri, Mark Prausnitz
https://vaccineresources.org/delivery-technologies.php
Innovative methods such as intradermal delivery also hold promise for reducing the quantity of vaccine required for an effective dose—potentially helping to decrease costs for immunization programs and expand access to vaccines in limited supply. PATH is working to improve vaccine delivery through the exploration and development of new ...
https://www.sciencedirect.com/science/article/pii/S0264410X12016143
Jul 25, 2013 · Highlights Intradermal delivery can enable dose sparing with some vaccines. Novel delivery devices may enable safer, more reliable intradermal delivery. Novel intradermal delivery devices may also enable vaccine dose sparing. Some clinical data show the potential of dose sparing via the intradermal route. Many challenges remain before the benefits of intradermal delivery can be realized.Author: Darin Zehrung, Courtney Jarrahian, Amy Wales
https://www.researchgate.net/publication/50290385_Intradermal_delivery_of_vaccines_Potential_benefits_and_current_challenges
The data obtained with intradermal delivery of some vaccines are encouraging and warrant further study and development; however significant gaps in knowledge and operational challenges such as ...
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