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https://link.springer.com/chapter/10.1007%2F978-3-642-00477-3_1
Nov 19, 2009 · Drug carriers are expected to stay in the blood for long time, accumulate in pathological sites with affected and leaky vasculature (tumors, inflammations, and infarcted areas) via the enhanced permeability and retention (EPR) effect, and facilitate targeted delivery of specific ligand-modified drugs and drug carriers into poorly accessible areas.Author: Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179822/
Jul 23, 2014 · 2. Passive targeting. In passive targeting, macromolecules including nanoparticles accumulate preferentially in the neoplastic tissues as a result of the enhanced permeability and retention (EPR) phenomenon, first described by Maeda and Matsumura (7,8).The EPR is based on the nanometer size range of the nanoparticles and two fundamental characteristics of the neoplastic tissues, namely, …Author: Remon Bazak, Mohamad Houri, Samar El Achy, Wael Hussein, Tamer Refaat
https://onlinelibrary.wiley.com/doi/full/10.1111/jphp.13098
Nuclear targeting. Beside the drug delivery to the TME or more precisely to the tumour cells, some treatments need an even more precise level which is the drug delivery at organelle level, for example, nucleus, lysosomes, mitochondria or endoplasmic reticulum.Author: Mohamed F. Attia, Mohamed F. Attia, Nicolas Anton, Justine Wallyn, Ziad Omran, Thierry F. Vandamme
https://www.medscape.com/viewarticle/770397_3
Nov 06, 2019 · Targeting Strategies . Two basic requirements should be realized in the design of nanocarriers to achieve effective drug delivery (Figure 2). First, drugs should be able to …
https://www.hindawi.com/journals/jnm/2016/1087250/
Drug delivery targeting is classified as passive, active, or physical and can target organs, cells, or organelles. Organelle targeting is an especially promising field of research, as many cancers specifically affect a single one, and certain organelles provide alternative paths for drug localization. 3.2. Passive Targeting Nanocarrier SystemsAuthor: Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, Zi Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · So-called “passive targeting” is based on drug accumulation in the areas around the tumors with leaky vasculature; commonly referred to as the enhanced permeation and retention (EPR) effect (more on the EPR effect below). Passive targeting happens to almost all drug carriers whether such distribution is intended or not.Author: You Han Bae, Kinam Park
https://www.researchgate.net/publication/41850483_Passive_and_Active_Drug_Targeting_Drug_Delivery_to_Tumors_as_an_Example
There are two strategies for active and passive targeting in the design of drug delivery systems. In passive targeting, anatomical discrepancies between the normal tissue and the overtaken tissue ...
https://www.youtube.com/watch?v=Up0RclkzeOY
May 04, 2017 · This Video describes about how liposomes acts as drug carriers in targeted drug delivery system.Author: Chakka Tharun
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/targeted-drug-delivery
7 Nanoparticles for Cancer Drug Delivery: Active versus Passive Targeting. Targeted drug delivery by conjugating with a biocompatible polymer allowing better solubility, lower toxicity, and prolonged release forms the basis of cancer medicine. In the past few decades unprecedented endeavors have been made in the development of nanomaterials ...
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