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https://www.tandfonline.com/doi/full/10.1517/17425247.2013.745509
Feb 27, 2013 · The progress made in comprehending the function and structure of tight junctions has contributed to advances in terms of enhanced drug delivery through the paracellular pathway. Although tight junction modulation holds great potential for effective oral delivery of poorly absorbable drugs, many challenges still need to be overcome before more clinically successful formulations could be …Author: Hendrik Jacobus Righard Lemmer, Josias H. Hamman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445828/
Some progress has been made in enhancing drug delivery via the paracellular pathway by modulating the intercellular junction proteins. It is predicted that this method has a future in oral delivery of large molecules such as peptides, proteins, and oligonucleotides.Author: Marlyn Laksitorini, Vivitri D. Prasasty, Paul K. Kiptoo, Teruna J. Siahaan
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/paracellular-transport
Paracellular transport is of interest for the delivery of hydrophilic and macromolecular drugs and for molecules that would otherwise be degraded during transcellular passage. Paracellular transport is less selective with respect to size, charge, and hydrophobicity of the solute than is either passive diffusion or transporter-mediated processes.
https://patents.google.com/patent/CA2379661A1/en
The present invention provides a paracellular drug delivery system, related to Claudin-6. In another aspect of the present invention there is provided a composition comprising the...Author: Kursad Turksen
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Oral drug delivery is the most popular and economical route of drug administration. Barriers to oral drug delivery include solubility and dissolution, absorption, presystemic metabolism, and excretion.
http://www.eurekaselect.com/56543/article
Keywords:Blood-brain barrier, claudin, drug delivery, E-cadherin, intestinal mucosa, JAM, paracellular permeation, tight junctions. Abstract: The delivery of large hydrophilic molecules (i.e., peptides and proteins) across biological barriers has been hampered by the presence of tight junctions. This delivery process can be improved by enhancing permeation through intercellular junctions of the intestinal …Author: Kai Zheng, Maulik Trivedi, Teruna J. Siahaan
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