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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815202/
The most commonly used carriers for drug delivery in pancreatic cancer treatment include liposomes, nanoparticles, and carbon nanotubes. Those carriers can protect the drugs from degradation and will effectively deliver them to the target organs.
https://www.sciencedirect.com/science/article/pii/S0304419X09000729
The most commonly used carriers for drug delivery in pancreatic cancer treatment include liposomes, nanoparticles, and carbon nanotubes (Fig. 1). These carriers can protect the drugs from degradation and will effectively deliver them to the target organs.Author: Xianjun Yu, Yuqing Zhang, Changyi Chen, Qizhi Yao, Min Li
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551211/
Mar 30, 2012 · Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeutic target in PDA.Author: Michael A Jacobetz, Derek S Chan, Albrecht Neesse, Tashinga E Bapiro, Natalie Cook, Kristopher K Fre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424495/
Rationale for using nanoparticles in pancreatic cancer Hydrophobicity can limit the effect a drug might manifest against a tumor since efficient antitumor activity requires delivery through aqueous compartments. Addition of various excipients is currently used to provide hydrophilic properties.Author: Anastasios Dimou, Konstantinos N. Syrigos, Muhammad Wasif Saif
https://www.pancan.org/research/strategic-research-program/news/new-strategy-to-improve-drug-delivery-to-pancreatic-tumors/
Since chemotherapeutics and other cancer drugs are administered intravenously, the poor blood supply to pancreatic tumors also impedes drug delivery. A mouse model of pancreatic cancer that Dr. Hingorani helped develop mimics this feature of human pancreatic cancer.
http://pancreatic.org/chemotherapy-nanoparticles-offer-breakthrough-in-pancreatic-cancer-drug-delivery/
Apr 18, 2017 · Pancreatic ductal adenocarcinoma is generally a fatal disease, with a five-year survival rate of less than 6 percent. The introduction of nanocarriers as delivery vehicles for common chemotherapy agents such as the drug irinotecan, has led to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929070/
In summary, delivery has been the confounding factor for using the novel Survivin-T34A as an effective therapeutic. This study not only adds to the importance of using Survivin-T34A as a cancer therapeutic for the treatment of pancreatic cancer, but that exosome delivery may provide a potential mechanism for effective tumour delivery.Author: Jonathan R. Aspe, Carlos J. Diaz Osterman, Jessica M.S. Jutzy, Simone Deshields, Sonia Whang, Nathan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503627/
It has been demonstrated in various cancer types, including pancreatic cancer, that curcumin’s solubility and efficacy is enhanced by liposomal delivery in vitro and in vivo with minimal toxicity, providing promising evidence for clinical application [35–38].Author: Carlos J. Diaz Osterman, James C. Lynch, Patrick Leaf, Amber Gonda, Heather R. Ferguson Bennit, Dunc...
http://www.jnsci.org/files/html/e124.htm
9 rows · Curcumin and Pancreatic Cancer: A Research and Clinical Update Pancreatic cancer is …
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