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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806207/
Feb 18, 2013 · The encapsulation of paclitaxel in biodegradable and non-toxic nano-delivery systems can protect the drug from degradation during circulation and in-turn protect the body from toxic side effects of the drug thereby lowering its toxicity, increasing its circulation half-life, exhibiting improved pharmacokinetic profiles, and demonstrating better patient compliance.Author: Ping Ma, Russell J. Mumper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425796/
Aug 12, 2012 · Among alternative experimental delivery systems of paclitaxel, nanoparticles of various biodegradable polymers and bioadhesive materials have been considered as promising. Nanotechnology can help to improve the bioavailability of poorly soluble drugs such as paclitaxel, enhancing drug delivery . Nanoparticles also have the ability to permeate through certain tissues, adding to their drug …Author: Madhu S. Surapaneni, Sudip K. Das, Nandita G. Das
https://news.northwestern.edu/stories/2019/07/trojan-horse-anticancer-drug-delivery-disguises-itself-as-fat/
In the study, the researchers used the drug delivery system to carry a common, FDA-approved chemotherapy drug, paclitaxel, into tumors in a small animal model. Disguised as fat, the drug entered and completely eliminated the tumors in three types of cancer: bone, pancreatic and colon.
https://www.researchgate.net/publication/234068190_Paclitaxel_drug_delivery_systems
Paclitaxel drug delivery systems. Introduction: Paclitaxel (PTX) is one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers. However, its clinical application has been limited due to its poor water solubility.
http://www.eurekaselect.com/122660/article
Keywords:Cancer, drug delivery systems, liposomes, nanoparticles, paclitaxel. Abstract:Paclitaxel (PTX), a taxane plant product, is one of the most effective broad-spectrum anti-cancer agents and approved for the treatment of a variety of cancers including ovarian, breast, lung, head and neck as well as Kaposi’s sarcoma.
https://onlinelibrary.wiley.com/doi/full/10.1111/resp.13214
ABSTRACT Background and objective Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing …Author: Hisashi Tsukada, Plamena Entcheva-Dimitrov, Armin Ernst, Samaan Rafeq, John H. Keating, Kirk P. Sewa...
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