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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762612/
Aug 19, 2013 · Inhibition of P-gp. The inhibition of efflux pump is mainly done in order to improve the delivery of therapeutic agents. In general, P-gp can be inhibited by three mechanisms: (i) blocking drug binding site either competitively, non-competitively (Fig. 2) or allosterically; (ii) interfering with ATP hydrolysis; and (iii) altering integrity of cell membrane lipids. 1, 10, 17 – 19 The goal is ...Author: Md. Lutful Amin
https://journals.sagepub.com/doi/pdf/10.4137/DTI.S12519
P-glycoprotein inhibition for optimal drug delivery Drug Target Insights 2013:7 29 (verapamil, cyclosporin A, trans-flupenthixol, etc.) are themselves transported …
https://journals.sagepub.com/doi/10.4137/DTI.S12519
Aug 19, 2013 · The inhibition of efflux pump is mainly done in order to improve the delivery of therapeutic agents. In general, P-gp can be inhibited by three mechanisms: (i) blocking drug binding site either competitively, non-competitively or allosterically; (ii) interfering with ATP hydrolysis; and (iii) altering integrity of cell membrane lipids. 1,10,17– 19 The goal is to achieve improved drug ...Author: Md. Lutful Amin
https://www.ncbi.nlm.nih.gov/pubmed/24023511
Aug 19, 2013 · 1. Drug Target Insights. 2013 Aug 19;7:27-34. doi: 10.4137/DTI.S12519. P-glycoprotein Inhibition for Optimal Drug Delivery. Amin ML(1). Author information: (1)Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh. P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and …Author: Md. Lutful Amin
https://www.researchgate.net/publication/256491297_P-glycoprotein_Inhibition_for_Optimal_Drug_Delivery
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic ...
https://www.researchgate.net/publication/338385539_INTERNATIONAL_JOURNAL_OF_PHARMACEUTICAL_CHEMICAL_AND_BIOLOGICAL_SCIENCES_PLASMA_GLYCOPROTEIN_INHIBITORS_AS_A_NEW_TARGET_FOR_OPTIMAL_DRUG_DELIVERY
TARGET FOR OPTIMAL DRUG DELIVERY. Alla ... administered drugs via induction or inhibition has been also been demonstrated in various studies. ... probably due to efflux of drug by a P-glycoprotein ...
https://physiologyforhippies.com/what-is-p-glycoprotein/
You may have heard of p-glycoprotein as an "efflux membrane transporter" or a "multidrug resistance pump." If you looked at those words and then thought, "yes, but what is it?" then you're in luck. I've made a quick video covering the basics here.
https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-019-0146-5
Aug 22, 2019 · BECs help maintain brain homeostasis and they possess an array of efflux transporters, such as P-glycoprotein (P-gp), that function to efflux potentially harmful compounds from the CNS back into the circulation. Oftentimes, efflux also serves to limit the brain uptake of therapeutic drugs, representing a major hurdle for CNS drug delivery.Author: Brandon J. Kim, Brandon J. Kim, Maura A. McDonagh, Liwen Deng, Benjamin D. Gastfriend, Alexandra Sch...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/glycoprotein-p-inhibitor
The second method of P-glycoprotein inhibition assessment is to use 99m Tc-SESTAMIBI (Bakker et al., 1999).This is a most unusual P-glycoprotein substrate because it is very hydrophilic (Piwnica-Worms et al., 1993).However, it is a nearly perfect tracer because it is not metabolized and provides very clean images with little background.
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