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https://handbook.ggcmedicines.org.uk/guidelines/gastrointestinal-system/management-of-gastroduodenal-ulcers/#:~:text=continuous%20infusion%2A%20of%208%20mg%2Fhour%20for%2072%20hours,6%20weeks.%20%2A%20This%20is%20an%20unlicensed%20indication.
https://pubmed.ncbi.nlm.nih.gov/27275859/
One group (second-look endoscopy group) received the proton pump inhibitor (PPI) omeprazole as an intravenous bolus every 12 hours for 72 hours and a second endoscopy within 16 - 24 hours with retreatment for persistent stigmata of bleeding. The other group (PPI infusion group) received continuous high-dose omeprazole infusion for 72 hours.
https://pubmed.ncbi.nlm.nih.gov/10022628/
Thus, we have compared the antisecretory effect of high dose omeprazole and ranitidine infusion and injection over the critical first 72 h. Methods: A total of 34 healthy volunteers were randomized into a double-blind crossover 72 h intragastric pH-metry study (data compared: median pH, percentage of time with pH >4 and pH >6). Omeprazole-infusion: initial bolus of 80 mg + 8 mg/h; omeprazole-injection: …
https://bnf.nice.org.uk/drug/omeprazole.html
Initially 80 mg, to be given over 40–60 minutes, then (by continuous intravenous infusion) 8 mg/hour for 72 hours, subsequent dose then changed to oral therapy. Unlicensed use. With oraluse. Duration of treatment for gastro-oesophageal reflux disease differs from …
https://www.gloshospitals.nhs.uk/documents/2053/IntravenousPPI.pdf
patients should be given intravenous omeprazole 40mg BD for 72 hours, of which the first dose should be prescribed stat. This should be given as a short infusion in 100ml 0.9% sodium chloride or 5% glucose over 20-30 minutes. After 72 hours of IV treatment patients should be …
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