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https://pubmed.ncbi.nlm.nih.gov/27275859/
One group (second-look endoscopy group) received the proton pump inhibitor (PPI) omeprazole as an intravenous bolus every 12 hours for 72 hours and a second endoscopy within 16 - 24 hours with retreatment for persistent stigmata of bleeding. The other group (PPI infusion group) received continuous high-dose omeprazole infusion for 72 hours.Cited by: 13
https://pubmed.ncbi.nlm.nih.gov/10022628/
Thus, we have compared the antisecretory effect of high dose omeprazole and ranitidine infusion and injection over the critical first 72 h. Methods: A total of 34 healthy volunteers were randomized into a double-blind crossover 72 h intragastric pH-metry study (data compared: median pH, percentage of time with pH >4 and pH >6). Omeprazole-infusion: initial bolus of 80 mg + 8 mg/h; omeprazole-injection: initial bolus of 80 mg + 40 …Cited by: 227
https://www.nejm.org/doi/full/10.1056/NEJM200008033430501
Furthermore, tolerance of the antisecretory effect of H 2-receptor antagonists, with loss of pH control, develops during the 72-hour period of infusion. 6 Thus, a high-dose proton-pump inhibitor ...Cited by: 878
https://clinicaltrials.gov/ct2/show/NCT04170270
Nov 20, 2019 · Regarding group B, continuous infusion of omeprazole will be administrated at a rate of 8 mg/hour, for 72 hours. Active Comparator: intravenous omeprazole. intravenous omeprazole in bleeding peptic ulcer after endoscopic therapy as continuous infusion at rate of 8 mg/hour for 72 hours. Drug: Omeprazole.Allocation: Randomized
https://www.surreyandsussex.nhs.uk/wp-content/uploads/2013/04/UKMi-IV-PPIs.pdf
8mg/hour infusion for 72 hours) should be used in patients with major peptic ulcer bleeding following endoscopic haemostatic therapy (8,9,10). ♦ Omeprazole and pantoprazole are not licensed to be given by continuous intravenous infusion (4,5) and use in this way is therefore the responsibility of the prescribing physician. Intravenous
https://www.gloshospitals.nhs.uk/documents/2053/IntravenousPPI.pdf
patients should be given intravenous omeprazole 40mg BD for 72 hours, of which the first dose should be prescribed stat. This should be given as a short infusion in 100ml 0.9% sodium chloride or 5% glucose over 20-30 minutes. After 72 hours of IV treatment patients should be converted to 20mg PO omeprazole BD.
https://www.gastrojournal.org/article/S0016-5085(94)94341-9/pdf
pH > 4 are shown for the entire 72-hour period and for individual days 1, 2, and 3 in Figure 1. The median pH with omeprazole infusion was 5.5 (interquartile range, 5.4-5.5) in the entire 72-hour period; it was 5.5 (5.3- 5.6) on day 1, 5.4 (5.1-5.5) on day 2, and 5.5 (5.4- 5.6) on day 3.
https://bnf.nice.org.uk/drug/omeprazole.html
Initially 80 mg, to be given over 40–60 minutes, then (by continuous intravenous infusion) 8 mg/hour for 72 hours, subsequent dose then changed to oral therapy. Unlicensed use With oral use
https://en.wikipedia.org/wiki/Zimor
The duration of inhibition is up to 72 hours. When omeprazole is stopped, baseline stomach acid secretory activity returns after 3 to 5 days. The inhibitory effect of omeprazole on acid secretion will plateau after 4 days of repeated daily dosing. Pharmacokinetics. The absorption of …
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