We have collected information about Overcoming Lung Clearance Mechanisms For Controlled Release Drug Delivery for you. Follow the links to find out details on Overcoming Lung Clearance Mechanisms For Controlled Release Drug Delivery.
https://link.springer.com/chapter/10.1007%2F978-1-4419-9745-6_5
May 25, 2011 · For controlled drug delivery to the lung, however, the goal is to slow or evade these clearance mechanisms using biocompatible systems that elicit no inflammatory response but allow modulated drug release. In this chapter, we introduce briefly the principles of the lung clearance mechanisms including mucociliary, absorptive, phagocytic,...Author: Ibrahim M. El-Sherbiny, Ibrahim M. El-Sherbiny, Diana G. Villanueva, Dea Herrera, Hugh D. C. Smyth
https://www.researchgate.net/publication/226848091_Overcoming_Lung_Clearance_Mechanisms_for_Controlled_Release_Drug_Delivery
Overcoming Lung Clearance Mechanisms for Controlled Release Drug Delivery. The lung anatomy and physiology is well adapted to handle exogenous aerosols and rapidly process them for clearance. Only in a few circumstances in nature are these defenses breached, with dire consequences, as in the case of asbestos.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386009/
Mar 31, 2015 · Although these clearance mechanisms maintain the sterility of the lung, clearance mechanisms can also act as barriers to the therapeutic effectiveness of inhaled drugs. This effectiveness is also influenced by the deposition site and delivered dose.Author: Ibrahim M. El-Sherbiny, Nancy M. El-Baz, Magdi H. Yacoub
https://www.sciencedirect.com/science/article/pii/037851739500104Q
However, the strategy of producing long- acting drug entities, which is also an active field, will not be discussed. 2. Liposomes Liposomes are one of the most extensively investigated systems for controlled delivery of drug to the lung, since they can be prepared with phospholipids endogenous to the lung as surfac- tants.Author: Xian Ming Zeng, Gary Peter Martin, Christopher Marriott
https://erj.ersjournals.com/content/44/3/765
Sep 01, 2014 · Inhaled particles can be cleared out of the lungs by two systems. In the conducting zone of the lung, particles can efficiently be removed by moving patches of mucus. This mechanism hinders drug delivery to the underlying epithelium, a difficulty that is worsened in lung diseases …Author: Sabine H. van Rijt, Thomas Bein, Silke Meiners
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for local and systemic treatment. Over the last 2 decades, the systemic absorption of a broad range of therapeutics after pulmonary application has been demonstrated in animals as well as in humans.
https://link.springer.com/book/10.1007/978-1-4419-9745-6
Controlled Pulmonary Drug Delivery begins by examination of the foundations for pulmonary drug delivery: the macro and microstructure of the airways, lung clearance, airway absorption and transport, aerosol physics, and a historical overview of the field. Unlike other texts, these chapters are written specifically with drug delivery in mind.
https://www.springer.com/gp/book/9781441997449
Controlled Pulmonary Drug Delivery begins by examination of the foundations for pulmonary drug delivery: the macro and microstructure of the airways, lung clearance, airway absorption and transport, aerosol physics, and a historical overview of the field. Unlike other texts, these chapters are written specifically with drug delivery in mind.
https://www.researchgate.net/publication/12394755_Sustained_Release_Drug_Delivery_to_the_Lungs
The advantages for sustained release drug delivery to the respiratory tract are numerous, and include extended duration of action, reduction in drug use, improved management of therapy, improved ...
https://books.google.com/books/about/Controlled_Pulmonary_Drug_Delivery.html?id=b8qaI_iOh0UC
Jun 24, 2011 · It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or …
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