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http://www.thepharmajournal.com/vol1Issue7/Issue_sept_2012/23.1.pdf
The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to deliver pharmacotherapy, usually once-daily, in several therapeutic areas. Oral route is one of the most extensively used routes of
https://www.sciencedirect.com/topics/nursing-and-health-professions/osmotic-controlled-release-oral-delivery-system
Concerta (OROS methylphenidate), the first of these novel delivery systems, has been available since August 2000. Concerta uses the OROS technology to deliver a 50:50 racemic mixture of d, l-threo-MPH. An 18-mg caplet of Concerta delivers the equivalent of 15 mg MPH (5 mg MPH three times per day) providing 12-hour coverage.
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2656329_ndt-3-869f1&req=4
The OROS technology results in reduced fluctuations between drug peak and trough serum concentrations (eg, 38% paliperidone ER versus 125% risperidone immediate-release [IR]) (Rossenu et al 2007). To preserve the integrity of the OROS delivery system, the tablet should be swallowed whole and not chewed, split or crushed (INVEGA package insert ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407637/
Jul 17, 2012 · 5.7. Liquid-Oral Osmotic (L-OROS) System. Various L-OROS systems available to provide controlled delivery of liquid drug formulations include L-OROS hardcap, L-OROS softcap, and a delayed liquid bolus delivery system. Each of these systems includes a liquid drug layer, an osmotic engine or push layer, and a semipermeable membrane coating.Author: Rajesh A. Keraliya, Chirag Patel, Pranav Patel, Vipul Keraliya, Tejal G. Soni, Rajnikant C. Patel, M...
http://ijpacr.com/files/05-5.pdf
The OROS-CT TM system was designed for colon-targeted drug delivery.Author: K. Raja Rao, V. Vasu Naik, A. Anka Rao, A. Rajesh
https://www.concerta.net/concerta-for-adults.html
CONCERTA ® is the only ADHD treatment with the unique OROS ® delivery system. One morning dose slowly releases methylphenidate at an increasing rate throughout the day. Adults with ADHD typically start on a daily dose of 18 or 36 mg of CONCERTA ®. …
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