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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
Vaccine delivery systems can be classified as follows. Solid particulates: Solid particulate systems such as microspheres and lipospheres are being exploited for vaccine delivery [Table 1] based on the fact that intestine is an imperfect barrier to small particulates. Antigens entrapped in such particulates when taken up by M-cells can generate immunity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403562/
Current applicable oral vaccine delivery systems are broadly categorized into the liposomal system, polymeric particles, and the adenoviral vector system, and with or without live attenuated vaccines application, which can be useful to increase vaccine potency via in vivo proliferation (Figure 3).Author: Sung Hun Kang, Seok Jin Hong, Yong-Kyu Lee, Sungpil Cho
https://www.hindawi.com/journals/jir/2019/8303648/
An effective immunization using oral vaccines is achieved when sufficient quantities of antigen are transported across the mucosal barrier by M cells into Peyer’s patches and subsequently presented to T cells by antigen-presenting cells (APCs) [11].Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.researchgate.net/publication/6719149_Delivery_systems_and_adjuvants_for_oral_vaccines
Numerous delivery systems and adjuvants have been evaluated for oral vaccine delivery, including live vectors, inert particles and bacterial toxins. Although developments in oral vaccines have been disappointing so far, in terms of the generation of products, the availability of a range...
https://www.longdom.org/proceedings/nanoparticles-as-oral-vaccine-delivery-systems-220.html
This method of vaccine delivery enables us to address a wide spectrum of vaccines for prophylactic and therapeutic use. Recently, we have been evaluating oral vaccines for cancer such as HPV, melanoma, ovarian, breast and prostate with encouraging results. Biography :
https://news.berkeley.edu/2017/03/08/oral-delivery-system-could-make-vaccination-needle-free/
Mar 08, 2017 · Oral delivery system could make vaccinations needle-free. Patients could one day self-administer vaccines using a needleless, pill-sized technology that jet-releases a stream of vaccine inside the mouth, according to a proof-of-concept study conducted at UC Berkeley.
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