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https://www.sciencedirect.com/science/article/pii/S1359644606003084
The oral route for peptide and protein drug delivery might be possible in the near future using innovative delivery systems. Although considerable efforts have been already made to develop oral delivery systems of macromolecules, extensive in vivo studies with these delivery systems have not been publicly reported.Author: Mariko Morishita, Nicholas A. Peppas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally 4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374550/
The ocular route may also be used for the systemic delivery of peptides and protein based pharmaceutical drugs. The ocular route is the choice for the localized delivery of ophthalmologically active peptide and protein for the treatment of ocular disease in the pharmaceutical dosage form of solutions, suspensions and ointment.
https://pubs.acs.org/doi/10.1021/cr000700m
Polymeric Nano/Microparticles for Oral Delivery of Proteins and Peptides. 2015,,, 1359-1380. DOI: 10.1201/b19038-63. Eric M Pridgen, Frank Alexis, Omid C Farokhzad. Polymeric nanoparticle drug delivery technologies for oral delivery applications. Expert Opinion on Drug Delivery 2015, 12 (9) , 1459-1473. DOI: 10.1517/17425247.2015.1018175.Author: Anurag Sood and, Ramesh Panchagnula
https://advances.sciencemag.org/content/6/14/eaba0145.full
10 days ago · Oral delivery is the preferred route of drug administration; yet, it is not compatible with a large number of biological drugs due to low oral availability . Consequently, parenteral injection is the only route of administration for most protein and peptide drugs in clinic, although it suffers from poor patient compliance and high treatment ...
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
PROTEIN ORAL DELIVERY TECHNOLOGY POD ™ POD technology developed by Oramed (Jerusalem, Israel), consists of enteric-coated capsules containing an oily suspension of the peptide drug, an enzyme inhibitor, such as soy bean trypsin inhibitor, aprotinin and an absorption enhancer such as EDTA or bile salt, in omega-3 fatty acids.
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