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https://www.ondrugdelivery.com/review-oral-peptide-delivery/
Figure 1: Table summarising selected oral peptide delivery technologies. MERRION’S GIPET ® TECHNOLOGY. Merrion Pharmaceuticals (Dublin, Ireland) is developing the GIPET® technology using an enteric coating (similar to Peptelligence ® and TPE technologies), in order to protect the peptide in the acidic gastric medium and ensure peptide release in the small intestine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo ...
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.nature.com/articles/s41573-019-0053-0
Dec 17, 2019 · Oral delivery of peptide therapeutics could have benefits for treatment adherence, but it faces barriers related to the structural organization and physiological function of the gastrointestinal ...Author: Daniel J. Drucker
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in …Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.ddw-online.com/therapeutics/p320747-oral-peptide-therapeutics-a-holy-grail-or-quixotic-quest.html
Challenges and opportunities in oral peptide therapeutic development. Numerous technologies are currently in development that are designed to enable the oral delivery of peptides. Though each has its unique set of properties and capabilities, all must overcome key obstacles to successfully deliver peptides via the oral route.
https://www.in-pharmatechnologist.com/Headlines/Promotional-Features/SEDDS-for-oral-peptide-delivery-Gattefosse-insight
Nov 13, 2017 · Conclusions. SEDDS is a simple and efficient platform to answer the growing need for oral peptide delivery. This technology is well-established for small molecules and has also successfully been applied for oral peptide delivery: Cyclosporin A (Neoral) is a SEDDS marked since the 1980’s.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
As oral delivery improves patient compliance, there is great interest in the development of systems that allow for the oral delivery of peptide and protein therapeutics . This review will summarize the barriers to various noninvasive delivery methods with a focus on oral and transdermal delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/S016836591830498X
Oral peptide delivery is an exciting area of research due to the scalability of tablets and capsules as drug products and the convenience it offers to patients, and hence …Author: Puneet Tyagi, Sergei Pechenov, J. Anand Subramony
https://www.researchgate.net/publication/263709483_Formulation_strategies_to_improve_oral_peptide_delivery
Delivery of peptides by the oral route greatly appeals due to commercial, patient convenience and scientific arguments. While there are over 60 injectable peptides marketed worldwide, and many ...
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