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https://www.researchgate.net/publication/263709483_Formulation_strategies_to_improve_oral_peptide_delivery
Formulation strategies to improve oral peptide delivery. ... Strategies to improve oral peptide delivery. Significant research effort has focused on improving peptide stability and permeation by .
https://epub.uni-regensburg.de/8515/1/ubr04037_ocr.pdf
Formulation and Delivery of Proteins and Peptides Jeffrey L. Cleland, EDITOR Genentech, Inc. Robert Langer, EDITOR Massachusetts Institute of Technology Developed from a symposium sponsored by the Division of Biochemical Technology at the 205th National Meeting of the American Chemical Society, Denver, Colorado, March 28-April 2,1993
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
The oral delivery of protein and peptide drugs A variety of strategies can be used to overcome the barriers to protein/ peptide drug delivery by the oral route. Dr Richard Soltero and Dr Nnochiri Ekwuribe, Nobex Corporation T he use of polypeptides and proteins for
https://www.ijpsonline.com/articles/properties-and-formulation-of-oral-drug-delivery-systems-of-protein-and-peptides.html
Mar 20, 2006 · Various novel carrier systems for protein and peptide drug delivery have been studied like lipid vesicles, particulate systems, emulsions, bioadhesive systems etc. Formulation approaches. A variety of approaches are adopted in formulating oral peptide delivery systems as per the nature of peptide drugs and the delivery matrix.
https://enterisbiopharma.com/
The technology has been developed and proven effective to enable the delivery of peptide-based therapeutics and other molecules with low oral bioavailability. In addition to its formulation development expertise, Enteris BioPharma has a 32,000 square-foot GMP facility in Boonton, New Jersey, offering a range of manufacturing services.
https://www.ondrugdelivery.com/magazines/novel-oral-delivery-systems-59/
Novel Oral Delivery Systems59. Issue No #59 July 2nd, 2015. Download PDF. Inside the magazine ... WHAT DO CUSTOMERS NEED IN ORAL DOSE DEVELOPMENT? ... Andy Lewis and Joël Richard provide an overview of the advantages provided, and challenges faced, by oral peptide delivery. GI/ORAL
http://drugdeliveryexperts.com/wp-content/uploads/2015/03/DDE-Introduction-20180727-1.pdf
• Peptide and small molecule chemistry, conjugation (e.g., PEGylation) • Lead candidate selection, optimizing pharmaceutical properties. Drug Product Development Strategic Partnership • Strategic product development and hands -on technical support • Participation in CMC teams (analytical, formulation, chemistry, device)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162733
Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced by intestinal cells and stimulates insulin secretion from the pancreas in a glucose-dependent manner. Exogenously supplied GLP-1 analogues are used in the treatment of type 2 diabetes. An anti-diabetic effect of Lactobacillus in lowering plasma glucose levels and its use as a vehicle for delivery of protein and antibody fragments ...
https://www.creative-peptides.com/blog/index.php/author/ppt/
Jan 14, 2020 · February 5, 2020 Frontiers in Peptides coronavirus, HR2P, peptide inhibitor ppt The 2019 Novel coronavirus is abbreviated by the World Health Organization. It is a positive-stranded single-stranded RNA coronavirus with an envelope, which is the pathogen of the pneumonia epidemic caused by the Read More…
https://link.springer.com/chapter/10.1007/978-3-642-79511-4_5
Designing means to deliver peptide and protein drugs successfully to the systemic circulation by the oral route has been a challenge to scientists in drug delivery for many years [1]. The barriers to peptide and protein absorption from the gastrointestinal tract are well …
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.
https://en.wikipedia.org/wiki/Drug_delivery
Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086064
Oral Delivery of Exenatide via Microspheres Prepared by Cross-Linking of Alginate and Hyaluronate ... These results further confirmed that microspheres prepared by cross-linking of alginate and hyaluronate with a specific cross-linking degree could be a valuable vehicle for the oral delivery of exenatide. ... (2005) Oral delivery of peptide ...
https://www.ddfevent.com/programme-2020
The Accordion Pill® (AP) oral delivery platform is a unique, film-based, gastro-retentive technology, developed by Intec Pharma. The AP technology allows multiple drug release profiles, enables high drug loading of both soluble and poorly soluble drugs, and can contain a fixed-dose combination.
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(97)01170-0
Conventional forms of administration for nonabsorbable drugs and peptides often rely on parenteral injection, because the intestinal epithelium represents a major barrier to the oral absorption of these therapeutic agents. Recently, a number of innovative drug-delivery approaches have been developed, including entrapment within small vesicles and passage through the space between adjacent ...
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