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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239698/
We think that development of a plant-based oral delivery system will be an ideal approach to overcome these aforementioned challenges and achieve clinical success. Therefore, our objective in this study was to develop a low-cost oral delivery system for administering ACE2 or Ang-(1-7) and test its efficacy in an experimental model of PH.Author: Vinayak Shenoy, Kwang-Chul Kwon, Anandharajan Rathinasabapathy, Shina Lin, Guiying Jin, Chunjuan Son...
https://www.ncbi.nlm.nih.gov/pubmed/25225206
Besides, fusion to a transmucosal carrier helps effective systemic absorption from the intestine on oral delivery. We hypothesized that bioencapsulating ACE2 or Ang-(1-7) fused to the cholera nontoxin B subunit would enable development of an oral delivery system that is effective in treating PH.Author: Vinayak Shenoy, Kwang-Chul Kwon, Anandharajan Rathinasabapathy, Shina Lin, Guiying Jin, Chunjuan Son...
https://www.sciencedirect.com/science/article/pii/S0268005X17319604
We report a novel oral delivery system based on sodium alginate/κ-carrageenan binary polysaccharide gel bead. β-galactase was selected as a model molecule to evaluate the capacity of the beads as delivery system. After enzyme encapsulation, the hydrogel beads were subsequently coated with κ-carrageenan (κ-CG) and ε-polylysine (ε-PL).Author: Yi-Wei Wang, Li-Ye Chen, Feng-Ping An, Man-Qian Chang, Hong-Bo Song
https://www.sciencedirect.com/science/article/pii/S0169409X16300278
Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts ... Strategies for oral delivery of macromolecular drugs that act on local or systemic targets. In buccal or sublingual delivery, the drug targets the buccal or sublingual mucosa, which avoids degradation pathways in the GI tract. ... Numerous oral enzyme ...Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://novel-drugdelivery-systems.pharmaceuticalconferences.com/speaker-keynote-pdfs/2016/joel-richard-ipsen-france.pdf
Oral Peptide Delivery: Successful Technologies Progressing in the Clinic and Future Challenges 8th International Conference & Exhibition on Pharmaceutics & Novel Drug Delivery Systems March 7-9, 2016 Madrid, Spain J. Richard, PhD Senior Vice President, Peptides 2016
http://www.pharmtech.com/oral-insulin-delivery-strategies-using-absorption-promoters-absorption-enhancers-and-protease-inhibi
Apr 02, 2006 · Oral insulin delivery strategies. Enzyme-inhibiting agents. Enzyme inhibiting agents are becoming increasingly popular as a delivery strategy for oral insulin. Insulin, like many other protein and peptide drugs, may be degraded in the gastrointestinal tract (GIT) by digestive enzymes such as pepsin, proteases, peptidases, and other proteolytic ...
http://www.pharmtech.com/oral-delivery-biologic-apis-challenge-continues
Mar 02, 2017 · The oral delivery of biologic APIs--mainly peptides and proteins--has been a “holy grail” of pharmaceutical drug delivery for the past several decades, according to Lyon. “Oral delivery remains the preferred route for delivery of medicines.
http://onlinelibrary.wiley.com/doi/10.1111/pbi.12366/abstract
Sep 21, 2015 · These results demonstrate that the oral administration of proteins encapsulated in plant cells is feasible. Specifically, carrot cells containing recombinant human prGCD can be used as an oral delivery system and are a feasible alternative to intravenous administration of ERT for GD.
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