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https://www.pharmaceutical-journal.com/drug-delivery-progress-and-problems/20003039.article
Professor LESLIE BENET (University of California, San Francisco) explained how oral drug delivery was affected. He said that, until relatively recently, poor oral bioavailability of a drug was thought to be related to physico-chemical problems or hepatic first pass metabolism.
https://www.contractpharma.com/issues/2018-05-01/view_features/pediatric-oral-drug-delivery-challenges-and-solutions/
Pediatric Oral Drug Delivery: Challenges and Solutions ... There is a growing trend away from liquid-based doses to flexible oral solid formulations. 5 Another problem, whether it is a solid or liquid dosage form, is ensuring the correct dose is measured and given to …
https://www.pharmaceutical-journal.com/drug-delivery-progress-and-problems/20003039.fullarticle
Professor LESLIE BENET (University of California, San Francisco) explained how oral drug delivery was affected. He said that, until relatively recently, poor oral bioavailability of a drug was thought to be related to physico-chemical problems or hepatic first pass metabolism.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225504/
In the future, further research and development are needed to solve the following main problems of oral drug delivery via nanocarriers: (1) an enhanced penetration of the intestinal mucus barrier, (2) reliable uptake by enterocytes or other intestinal cell types, (3) enhanced efficiencies for the transversal of the intestinal cell barrier, in particular a solution for the often problematic trafficking into the …Author: Jonas Reinholz, Katharina Landfester, Volker Mailänder
https://www.researchgate.net/topic/Oral-Drug-Delivery
Dec 07, 2019 · In oral administration, a drug has to pass through the gut, gut wall and liver before reaching the systemic circulation. Some drugs may undergo substantial pre-systemic metabolism …
https://emisphere.com/barriers/
Emisphere's Eligen ® Technology overcomes major obstacles to effective oral delivery including: Degradation. The high acid content and enzymes of the digestive tract can degrade some drugs, particularly protein and peptide drugs, before they are absorbed into the bloodstream.
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